Oppermann U - Search Results

1

High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships.

Niesen FH, Schultz L, Jadhav A, Bhatia C, Guo K, Maloney DJ, Pilka ES, Wang M, Oppermann U, Heightman TD, Simeonov A. Niesen FH, et al. Among authors: oppermann u. PLoS One. 2010 Nov 2;5(11):e13719. doi: 10.1371/journal.pone.0013719. PLoS One. 2010. PMID: 21072165 Free PMC article.

2

Structural basis for substrate specificity in human monomeric carbonyl reductases.

Pilka ES, Niesen FH, Lee WH, El-Hawari Y, Dunford JE, Kochan G, Wsol V, Martin HJ, Maser E, Oppermann U. Pilka ES, et al. Among authors: oppermann u. PLoS One. 2009 Oct 20;4(10):e7113. doi: 10.1371/journal.pone.0007113. PLoS One. 2009. PMID: 19841672 Free PMC article.

3

Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors.

King ON, Li XS, Sakurai M, Kawamura A, Rose NR, Ng SS, Quinn AM, Rai G, Mott BT, Beswick P, Klose RJ, Oppermann U, Jadhav A, Heightman TD, Maloney DJ, Schofield CJ, Simeonov A. King ON, et al. Among authors: oppermann u. PLoS One. 2010 Nov 23;5(11):e15535. doi: 10.1371/journal.pone.0015535. PLoS One. 2010. PMID: 21124847 Free PMC article.

4

Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A.

Kochan G, Pilka ES, von Delft F, Oppermann U, Yue WW. Kochan G, et al. Among authors: oppermann u. J Mol Biol. 2009 May 22;388(5):997-1008. doi: 10.1016/j.jmb.2009.03.064. Epub 2009 Apr 1. J Mol Biol. 2009. PMID: 19345228

5

Crystal structure of human carbonic anhydrase-related protein VIII reveals the basis for catalytic silencing.

Picaud SS, Muniz JR, Kramm A, Pilka ES, Kochan G, Oppermann U, Yue WW. Picaud SS, et al. Among authors: oppermann u. Proteins. 2009 Aug 1;76(2):507-11. doi: 10.1002/prot.22411. Proteins. 2009. PMID: 19360879 No abstract available.

6

Crystal structure of the secretory isozyme of mammalian carbonic anhydrases CA VI: implications for biological assembly and inhibitor development.

Pilka ES, Kochan G, Oppermann U, Yue WW. Pilka ES, et al. Among authors: oppermann u. Biochem Biophys Res Commun. 2012 Mar 16;419(3):485-9. doi: 10.1016/j.bbrc.2012.02.038. Epub 2012 Feb 14. Biochem Biophys Res Commun. 2012. PMID: 22366092

7

Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family.

Chaikuad A, Pilka ES, De Riso A, von Delft F, Kavanagh KL, Vénien-Bryan C, Oppermann U, Yue WW. Chaikuad A, et al. Among authors: oppermann u. BMC Struct Biol. 2012 Jun 21;12:14. doi: 10.1186/1472-6807-12-14. BMC Struct Biol. 2012. PMID: 22720794 Free PMC article.

8

Towards a systematic analysis of human short-chain dehydrogenases/reductases (SDR): Ligand identification and structure-activity relationships.

Bhatia C, Oerum S, Bray J, Kavanagh KL, Shafqat N, Yue W, Oppermann U. Bhatia C, et al. Among authors: oppermann u. Chem Biol Interact. 2015 Jun 5;234:114-25. doi: 10.1016/j.cbi.2014.12.013. Epub 2014 Dec 16. Chem Biol Interact. 2015. PMID: 25526675

9

Discovery of NCT-501, a Potent and Selective Theophylline-Based Inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1).

Yang SM, Yasgar A, Miller B, Lal-Nag M, Brimacombe K, Hu X, Sun H, Wang A, Xu X, Nguyen K, Oppermann U, Ferrer M, Vasiliou V, Simeonov A, Jadhav A, Maloney DJ. Yang SM, et al. Among authors: oppermann u. J Med Chem. 2015 Aug 13;58(15):5967-78. doi: 10.1021/acs.jmedchem.5b00577. Epub 2015 Jul 24. J Med Chem. 2015. PMID: 26207746 Free PMC article.

10

Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.

Ng SS, Kavanagh KL, McDonough MA, Butler D, Pilka ES, Lienard BM, Bray JE, Savitsky P, Gileadi O, von Delft F, Rose NR, Offer J, Scheinost JC, Borowski T, Sundstrom M, Schofield CJ, Oppermann U. Ng SS, et al. Among authors: oppermann u. Nature. 2007 Jul 5;448(7149):87-91. doi: 10.1038/nature05971. Epub 2007 Jun 24. Nature. 2007. PMID: 17589501

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