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Transplantation of mouse HSCs genetically modified to express a CD4-restricted TCR results in long-term immunity that destroys tumors and initiates spontaneous autoimmunity.
Ha SP, Klemen ND, Kinnebrew GH, Brandmaier AG, Marsh J, Hangoc G, Palmer DC, Restifo NP, Cornetta K, Broxmeyer HE, Touloukian CE. Ha SP, et al. Among authors: broxmeyer he. J Clin Invest. 2010 Dec;120(12):4273-88. doi: 10.1172/JCI43274. Epub 2010 Nov 15. J Clin Invest. 2010. PMID: 21084750 Free PMC article.
CD45 cell surface antigens are linked to stimulation of early human myeloid progenitor cells by interleukin 3 (IL-3), granulocyte/macrophage colony-stimulating factor (GM-CSF), a GM-CSF/IL-3 fusion protein, and mast cell growth factor (a c-kit ligand).
Broxmeyer HE, Lu L, Hangoc G, Cooper S, Hendrie PC, Ledbetter JA, Xiao M, Williams DE, Shen FW. Broxmeyer HE, et al. J Exp Med. 1991 Aug 1;174(2):447-58. doi: 10.1084/jem.174.2.447. J Exp Med. 1991. PMID: 1713254 Free PMC article.
713 results