Restifo NP - Search Results

1

Transplantation of mouse HSCs genetically modified to express a CD4-restricted TCR results in long-term immunity that destroys tumors and initiates spontaneous autoimmunity.

Ha SP, Klemen ND, Kinnebrew GH, Brandmaier AG, Marsh J, Hangoc G, Palmer DC, Restifo NP, Cornetta K, Broxmeyer HE, Touloukian CE. Ha SP, et al. Among authors: restifo np. J Clin Invest. 2010 Dec;120(12):4273-88. doi: 10.1172/JCI43274. Epub 2010 Nov 15. J Clin Invest. 2010. PMID: 21084750 Free PMC article.

2

High-avidity autoreactive CD4+ T cells induce host CTL, overcome T(regs) and mediate tumor destruction.

Brandmaier AG, Leitner WW, Ha SP, Sidney J, Restifo NP, Touloukian CE. Brandmaier AG, et al. Among authors: restifo np. J Immunother. 2009 Sep;32(7):677-88. doi: 10.1097/CJI.0b013e3181ab1824. J Immunother. 2009. PMID: 19561540 Free PMC article.

3

Poor immunogenicity of a self/tumor antigen derives from peptide-MHC-I instability and is independent of tolerance.

Yu Z, Theoret MR, Touloukian CE, Surman DR, Garman SC, Feigenbaum L, Baxter TK, Baker BM, Restifo NP. Yu Z, et al. Among authors: restifo np. J Clin Invest. 2004 Aug;114(4):551-9. doi: 10.1172/JCI21695. J Clin Invest. 2004. PMID: 15314692 Free PMC article.

4

Hematopoietic stem cells promote the expansion and function of adoptively transferred antitumor CD8 T cells.

Wrzesinski C, Paulos CM, Gattinoni L, Palmer DC, Kaiser A, Yu Z, Rosenberg SA, Restifo NP. Wrzesinski C, et al. Among authors: restifo np. J Clin Invest. 2007 Feb;117(2):492-501. doi: 10.1172/JCI30414. J Clin Invest. 2007. PMID: 17273561 Free PMC article.

5

Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells.

Gattinoni L, Klebanoff CA, Palmer DC, Wrzesinski C, Kerstann K, Yu Z, Finkelstein SE, Theoret MR, Rosenberg SA, Restifo NP. Gattinoni L, et al. Among authors: restifo np. J Clin Invest. 2005 Jun;115(6):1616-26. doi: 10.1172/JCI24480. J Clin Invest. 2005. PMID: 15931392 Free PMC article.

6

Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8+ T cells via TLR4 signaling.

Paulos CM, Wrzesinski C, Kaiser A, Hinrichs CS, Chieppa M, Cassard L, Palmer DC, Boni A, Muranski P, Yu Z, Gattinoni L, Antony PA, Rosenberg SA, Restifo NP. Paulos CM, et al. Among authors: restifo np. J Clin Invest. 2007 Aug;117(8):2197-204. doi: 10.1172/JCI32205. J Clin Invest. 2007. PMID: 17657310 Free PMC article.

7

Suppressors of cytokine signaling (SOCS) in T cell differentiation, maturation, and function.

Palmer DC, Restifo NP. Palmer DC, et al. Among authors: restifo np. Trends Immunol. 2009 Dec;30(12):592-602. doi: 10.1016/j.it.2009.09.009. Epub 2009 Oct 30. Trends Immunol. 2009. PMID: 19879803 Free PMC article. Review.

8

Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function.

Sukumar M, Liu J, Ji Y, Subramanian M, Crompton JG, Yu Z, Roychoudhuri R, Palmer DC, Muranski P, Karoly ED, Mohney RP, Klebanoff CA, Lal A, Finkel T, Restifo NP, Gattinoni L. Sukumar M, et al. Among authors: restifo np. J Clin Invest. 2013 Oct;123(10):4479-88. doi: 10.1172/JCI69589. Epub 2013 Sep 16. J Clin Invest. 2013. PMID: 24091329 Free PMC article.

9

The in vivo expansion rate of properly stimulated transferred CD8+ T cells exceeds that of an aggressively growing mouse tumor.

Hwang LN, Yu Z, Palmer DC, Restifo NP. Hwang LN, et al. Among authors: restifo np. Cancer Res. 2006 Jan 15;66(2):1132-8. doi: 10.1158/0008-5472.CAN-05-1679. Cancer Res. 2006. PMID: 16424050 Free PMC article.

10

Tumor-specific Th17-polarized cells eradicate large established melanoma.

Muranski P, Boni A, Antony PA, Cassard L, Irvine KR, Kaiser A, Paulos CM, Palmer DC, Touloukian CE, Ptak K, Gattinoni L, Wrzesinski C, Hinrichs CS, Kerstann KW, Feigenbaum L, Chan CC, Restifo NP. Muranski P, et al. Among authors: restifo np. Blood. 2008 Jul 15;112(2):362-73. doi: 10.1182/blood-2007-11-120998. Epub 2008 Mar 19. Blood. 2008. PMID: 18354038 Free PMC article.

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