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Inhibition of sphingosine 1-phosphate lyase for the treatment of rheumatoid arthritis: discovery of (E)-1-(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone oxime (LX2931) and (1R,2S,3R)-1-(2-(isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol (LX2932).
Bagdanoff JT, Donoviel MS, Nouraldeen A, Carlsen M, Jessop TC, Tarver J, Aleem S, Dong L, Zhang H, Boteju L, Hazelwood J, Yan J, Bednarz M, Layek S, Owusu IB, Gopinathan S, Moran L, Lai Z, Kramer J, Kimball SD, Yalamanchili P, Heydorn WE, Frazier KS, Brooks B, Brown P, Wilson A, Sonnenburg WK, Main A, Carson KG, Oravecz T, Augeri DJ. Bagdanoff JT, et al. Among authors: brown p. J Med Chem. 2010 Dec 23;53(24):8650-62. doi: 10.1021/jm101183p. Epub 2010 Nov 22. J Med Chem. 2010. PMID: 21090716 Clinical Trial.
LX4211, a dual SGLT1/SGLT2 inhibitor, improved glycemic control in patients with type 2 diabetes in a randomized, placebo-controlled trial.
Zambrowicz B, Freiman J, Brown PM, Frazier KS, Turnage A, Bronner J, Ruff D, Shadoan M, Banks P, Mseeh F, Rawlins DB, Goodwin NC, Mabon R, Harrison BA, Wilson A, Sands A, Powell DR. Zambrowicz B, et al. Among authors: brown pm. Clin Pharmacol Ther. 2012 Aug;92(2):158-69. doi: 10.1038/clpt.2012.58. Epub 2012 Jul 4. Clin Pharmacol Ther. 2012. PMID: 22739142 Free PMC article. Clinical Trial.
Safety and efficacy of fedratinib in patients with myelofibrosis previously treated with ruxolitinib: primary analysis of FREEDOM trial.
Gupta V, Yacoub A, Mesa RA, Harrison CN, Vannucchi AM, Kiladjian JJ, Deeg HJ, Fazal S, Foltz L, Mattison RJ, Miller CB, Parameswaran V, Brown P, Hernandez C, Wang J, Talpaz M. Gupta V, et al. Among authors: brown p. Leuk Lymphoma. 2024 Jun 5:1-11. doi: 10.1080/10428194.2024.2346733. Online ahead of print. Leuk Lymphoma. 2024. PMID: 38838026
Alcohol and substance use in older adults with treatment-resistant depression.
Srifuengfung M, Lenze EJ, Roose SP, Brown PJ, Lavretsky H, Karp JF, Reynolds CF 3rd, Yingling M, Sa-Nguanpanich N, Mulsant BH. Srifuengfung M, et al. Among authors: brown pj. Int J Geriatr Psychiatry. 2024 Jun;39(6):e6105. doi: 10.1002/gps.6105. Int J Geriatr Psychiatry. 2024. PMID: 38822571 Clinical Trial.
Effects of vitamin D supplementation on a deep learning-based mammographic evaluation in SWOG S0812.
McGuinness JE, Anderson GL, Mutasa S, Hershman DL, Terry MB, Tehranifar P, Lew DL, Yee M, Brown EA, Kairouz SS, Kuwajerwala N, Bevers TB, Doster JE, Zarwan C, Kruper L, Minasian LM, Ford L, Arun B, Neuhouser ML, Goodman GE, Brown PH, Ha R, Crew KD. McGuinness JE, et al. Among authors: brown ph. JNCI Cancer Spectr. 2024 May 30:pkae042. doi: 10.1093/jncics/pkae042. Online ahead of print. JNCI Cancer Spectr. 2024. PMID: 38814817
The New South Wales Mouse Plague 2020-2021: A One Health description.
White J, Taylor J, Brown PR, Henry S, Carter L, Mankad A, Chang WS, Stanley P, Collins K, Durrheim DN, Thompson K. White J, et al. Among authors: brown pr. One Health. 2024 May 9;18:100753. doi: 10.1016/j.onehlt.2024.100753. eCollection 2024 Jun. One Health. 2024. PMID: 38798736 Free PMC article.
6,922 results