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Inhibition of sphingosine 1-phosphate lyase for the treatment of rheumatoid arthritis: discovery of (E)-1-(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone oxime (LX2931) and (1R,2S,3R)-1-(2-(isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol (LX2932).
J Med Chem. 2010 Dec 23;53(24):8650-62. doi: 10.1021/jm101183p. Epub 2010 Nov 22.
J Med Chem. 2010.
PMID: 21090716
Clinical Trial.
Essential role of MAPK phosphatase-1 in the negative control of innate immune responses.
Salojin KV, Owusu IB, Millerchip KA, Potter M, Platt KA, Oravecz T.
Salojin KV, et al. Among authors: owusu ib.
J Immunol. 2006 Feb 1;176(3):1899-907. doi: 10.4049/jimmunol.176.3.1899.
J Immunol. 2006.
PMID: 16424221
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