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Discovery of CP-690,550: a potent and selective Janus kinase (JAK) inhibitor for the treatment of autoimmune diseases and organ transplant rejection.
J Med Chem. 2010 Dec 23;53(24):8468-84. doi: 10.1021/jm1004286. Epub 2010 Nov 24.
J Med Chem. 2010.
PMID: 21105711
Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor.
Changelian PS, Flanagan ME, Ball DJ, Kent CR, Magnuson KS, Martin WH, Rizzuti BJ, Sawyer PS, Perry BD, Brissette WH, McCurdy SP, Kudlacz EM, Conklyn MJ, Elliott EA, Koslov ER, Fisher MB, Strelevitz TJ, Yoon K, Whipple DA, Sun J, Munchhof MJ, Doty JL, Casavant JM, Blumenkopf TA, Hines M, Brown MF, Lillie BM, Subramanyam C, Shang-Poa C, Milici AJ, Beckius GE, Moyer JD, Su C, Woodworth TG, Gaweco AS, Beals CR, Littman BH, Fisher DA, Smith JF, Zagouras P, Magna HA, Saltarelli MJ, Johnson KS, Nelms LF, Des Etages SG, Hayes LS, Kawabata TT, Finco-Kent D, Baker DL, Larson M, Si MS, Paniagua R, Higgins J, Holm B, Reitz B, Zhou YJ, Morris RE, O'Shea JJ, Borie DC.
Changelian PS, et al. Among authors: blumenkopf ta.
Science. 2003 Oct 31;302(5646):875-8. doi: 10.1126/science.1087061.
Science. 2003.
PMID: 14593182
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2-Acetylpyridine thiocarbonohydrazones. Potent inactivators of herpes simplex virus ribonucleotide reductase.
Blumenkopf TA, Harrington JA, Koble CS, Bankston DD, Morrison RW Jr, Bigham EC, Styles VL, Spector T.
Blumenkopf TA, et al.
J Med Chem. 1992 Jun 12;35(12):2306-14. doi: 10.1021/jm00090a022.
J Med Chem. 1992.
PMID: 1319497
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Ryanodine action at calcium release channels. 1. importance of hydroxyl substituents.
Jefferies PR, Blumenkopf TA, Gengo PJ, Cole LC, Casida JE.
Jefferies PR, et al. Among authors: blumenkopf ta.
J Med Chem. 1996 Jun 7;39(12):2331-8. doi: 10.1021/jm950711l.
J Med Chem. 1996.
PMID: 8691427
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Inactivators of herpes simplex virus ribonucleotide reductase: hematological profiles and in vivo potentiation of the antiviral activity of acyclovir.
Spector T, Lobe DC, Ellis MN, Blumenkopf TA, Szczech GM.
Spector T, et al. Among authors: blumenkopf ta.
Antimicrob Agents Chemother. 1992 May;36(5):934-7. doi: 10.1128/AAC.36.5.934.
Antimicrob Agents Chemother. 1992.
PMID: 1324641
Free PMC article.
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Antibody-directed enzyme prodrug therapy with the T268G mutant of human carboxypeptidase A1: in vitro and in vivo studies with prodrugs of methotrexate and the thymidylate synthase inhibitors GW1031 and GW1843.
Wolfe LA, Mullin RJ, Laethem R, Blumenkopf TA, Cory M, Miller JF, Keith BR, Humphreys J, Smith GK.
Wolfe LA, et al. Among authors: blumenkopf ta.
Bioconjug Chem. 1999 Jan-Feb;10(1):38-48. doi: 10.1021/bc980057z.
Bioconjug Chem. 1999.
PMID: 9893962
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Toward antibody-directed enzyme prodrug therapy with the T268G mutant of human carboxypeptidase A1 and novel in vivo stable prodrugs of methotrexate.
Smith GK, Banks S, Blumenkopf TA, Cory M, Humphreys J, Laethem RM, Miller J, Moxham CP, Mullin R, Ray PH, Walton LM, Wolfe LA 3rd.
Smith GK, et al. Among authors: blumenkopf ta.
J Biol Chem. 1997 Jun 20;272(25):15804-16. doi: 10.1074/jbc.272.25.15804.
J Biol Chem. 1997.
PMID: 9188478
Free article.
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Expression and characterization of human pancreatic preprocarboxypeptidase A1 and preprocarboxypeptidase A2.
Laethem RM, Blumenkopf TA, Cory M, Elwell L, Moxham CP, Ray PH, Walton LM, Smith GK.
Laethem RM, et al. Among authors: blumenkopf ta.
Arch Biochem Biophys. 1996 Aug 1;332(1):8-18. doi: 10.1006/abbi.1996.0310.
Arch Biochem Biophys. 1996.
PMID: 8806703
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