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Discovery of CP-690,550: a potent and selective Janus kinase (JAK) inhibitor for the treatment of autoimmune diseases and organ transplant rejection.
J Med Chem. 2010 Dec 23;53(24):8468-84. doi: 10.1021/jm1004286. Epub 2010 Nov 24.
J Med Chem. 2010.
PMID: 21105711
Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor.
Changelian PS, Flanagan ME, Ball DJ, Kent CR, Magnuson KS, Martin WH, Rizzuti BJ, Sawyer PS, Perry BD, Brissette WH, McCurdy SP, Kudlacz EM, Conklyn MJ, Elliott EA, Koslov ER, Fisher MB, Strelevitz TJ, Yoon K, Whipple DA, Sun J, Munchhof MJ, Doty JL, Casavant JM, Blumenkopf TA, Hines M, Brown MF, Lillie BM, Subramanyam C, Shang-Poa C, Milici AJ, Beckius GE, Moyer JD, Su C, Woodworth TG, Gaweco AS, Beals CR, Littman BH, Fisher DA, Smith JF, Zagouras P, Magna HA, Saltarelli MJ, Johnson KS, Nelms LF, Des Etages SG, Hayes LS, Kawabata TT, Finco-Kent D, Baker DL, Larson M, Si MS, Paniagua R, Higgins J, Holm B, Reitz B, Zhou YJ, Morris RE, O'Shea JJ, Borie DC.
Changelian PS, et al. Among authors: magnuson ks.
Science. 2003 Oct 31;302(5646):875-8. doi: 10.1126/science.1087061.
Science. 2003.
PMID: 14593182
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The specificity of JAK3 kinase inhibitors.
Changelian PS, Moshinsky D, Kuhn CF, Flanagan ME, Munchhof MJ, Harris TM, Whipple DA, Doty JL, Sun J, Kent CR, Magnuson KS, Perregaux DG, Sawyer PS, Kudlacz EM.
Changelian PS, et al. Among authors: magnuson ks.
Blood. 2008 Feb 15;111(4):2155-7. doi: 10.1182/blood-2007-09-115030. Epub 2007 Dec 19.
Blood. 2008.
PMID: 18094329
Free article.
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Distinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activity.
Zhou YJ, Hanson EP, Chen YQ, Magnuson K, Chen M, Swann PG, Wange RL, Changelian PS, O'Shea JJ.
Zhou YJ, et al.
Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13850-5. doi: 10.1073/pnas.94.25.13850.
Proc Natl Acad Sci U S A. 1997.
PMID: 9391116
Free PMC article.
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Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases.
Zhou YJ, Chen M, Cusack NA, Kimmel LH, Magnuson KS, Boyd JG, Lin W, Roberts JL, Lengi A, Buckley RH, Geahlen RL, Candotti F, Gadina M, Changelian PS, O'Shea JJ.
Zhou YJ, et al. Among authors: magnuson ks.
Mol Cell. 2001 Nov;8(5):959-69. doi: 10.1016/s1097-2765(01)00398-7.
Mol Cell. 2001.
PMID: 11741532
Free article.
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Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation.
Zhou YJ, Magnuson KS, Cheng TP, Gadina M, Frucht DM, Galon J, Candotti F, Geahlen RL, Changelian PS, O'Shea JJ.
Zhou YJ, et al. Among authors: magnuson ks.
Mol Cell Biol. 2000 Jun;20(12):4371-80. doi: 10.1128/MCB.20.12.4371-4380.2000.
Mol Cell Biol. 2000.
PMID: 10825200
Free PMC article.
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