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Discovery of CP-690,550: a potent and selective Janus kinase (JAK) inhibitor for the treatment of autoimmune diseases and organ transplant rejection.
J Med Chem. 2010 Dec 23;53(24):8468-84. doi: 10.1021/jm1004286. Epub 2010 Nov 24.
J Med Chem. 2010.
PMID: 21105711
The novel JAK-3 inhibitor CP-690550 is a potent immunosuppressive agent in various murine models.
Kudlacz E, Perry B, Sawyer P, Conklyn M, McCurdy S, Brissette W, Flanagan And M, Changelian P.
Kudlacz E, et al.
Am J Transplant. 2004 Jan;4(1):51-7. doi: 10.1046/j.1600-6143.2003.00281.x.
Am J Transplant. 2004.
PMID: 14678034
Free article.
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Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor.
Changelian PS, Flanagan ME, Ball DJ, Kent CR, Magnuson KS, Martin WH, Rizzuti BJ, Sawyer PS, Perry BD, Brissette WH, McCurdy SP, Kudlacz EM, Conklyn MJ, Elliott EA, Koslov ER, Fisher MB, Strelevitz TJ, Yoon K, Whipple DA, Sun J, Munchhof MJ, Doty JL, Casavant JM, Blumenkopf TA, Hines M, Brown MF, Lillie BM, Subramanyam C, Shang-Poa C, Milici AJ, Beckius GE, Moyer JD, Su C, Woodworth TG, Gaweco AS, Beals CR, Littman BH, Fisher DA, Smith JF, Zagouras P, Magna HA, Saltarelli MJ, Johnson KS, Nelms LF, Des Etages SG, Hayes LS, Kawabata TT, Finco-Kent D, Baker DL, Larson M, Si MS, Paniagua R, Higgins J, Holm B, Reitz B, Zhou YJ, Morris RE, O'Shea JJ, Borie DC.
Changelian PS, et al. Among authors: sawyer ps.
Science. 2003 Oct 31;302(5646):875-8. doi: 10.1126/science.1087061.
Science. 2003.
PMID: 14593182
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The specificity of JAK3 kinase inhibitors.
Changelian PS, Moshinsky D, Kuhn CF, Flanagan ME, Munchhof MJ, Harris TM, Whipple DA, Doty JL, Sun J, Kent CR, Magnuson KS, Perregaux DG, Sawyer PS, Kudlacz EM.
Changelian PS, et al. Among authors: sawyer ps.
Blood. 2008 Feb 15;111(4):2155-7. doi: 10.1182/blood-2007-09-115030. Epub 2007 Dec 19.
Blood. 2008.
PMID: 18094329
Free article.
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Antagonizing leukotriene B4 receptors delays cardiac allograft rejection in mice.
Weringer EJ, Perry BD, Sawyer PS, Gilman SC, Showell HJ.
Weringer EJ, et al. Among authors: sawyer ps.
Transplantation. 1999 Mar 27;67(6):808-15. doi: 10.1097/00007890-199903270-00005.
Transplantation. 1999.
PMID: 10199727
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Activity of beta-lactamase inhibitor sulbactam plus ampicillin against animal isolates of Pasteurella, Haemophilus, and Staphylococcus.
Girard AE, Schelkly WU, Murphy KT, Sawyer PS.
Girard AE, et al. Among authors: sawyer ps.
Am J Vet Res. 1987 Dec;48(12):1678-83.
Am J Vet Res. 1987.
PMID: 3501686
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Sulbactam/ampicillin: in vitro spectrum, potency, and activity in models of acute infection.
Retsema JA, English AR, Girard A, Lynch JE, Anderson M, Brennan L, Cimochowski C, Faiella J, Norcia W, Sawyer P.
Retsema JA, et al.
Rev Infect Dis. 1986 Nov-Dec;8 Suppl 5:S528-34. doi: 10.1093/clinids/8.supplement_5.s528.
Rev Infect Dis. 1986.
PMID: 3026001
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A robust depolymerization route for polysiloxanes.
Warner MJ, Kopatz JW, Schafer DP, Kustas J, Sawyer PS, Grillet AM, Jones BH, Ghosh K.
Warner MJ, et al. Among authors: sawyer ps.
Chem Commun (Camb). 2024 Jan 25;60(9):1188-1191. doi: 10.1039/d3cc05509d.
Chem Commun (Camb). 2024.
PMID: 38193881
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