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Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers.
Fedele CG, Ooms LM, Ho M, Vieusseux J, O'Toole SA, Millar EK, Lopez-Knowles E, Sriratana A, Gurung R, Baglietto L, Giles GG, Bailey CG, Rasko JE, Shields BJ, Price JT, Majerus PW, Sutherland RL, Tiganis T, McLean CA, Mitchell CA. Fedele CG, et al. Among authors: tiganis t. Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22231-6. doi: 10.1073/pnas.1015245107. Epub 2010 Dec 2. Proc Natl Acad Sci U S A. 2010. PMID: 21127264 Free PMC article.
PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling.
Lu X, Malumbres R, Shields B, Jiang X, Sarosiek KA, Natkunam Y, Tiganis T, Lossos IS. Lu X, et al. Among authors: tiganis t. Blood. 2008 Nov 15;112(10):4098-108. doi: 10.1182/blood-2008-03-148726. Epub 2008 Aug 20. Blood. 2008. PMID: 18716132 Free PMC article.
Reactive oxygen species enhance insulin sensitivity.
Loh K, Deng H, Fukushima A, Cai X, Boivin B, Galic S, Bruce C, Shields BJ, Skiba B, Ooms LM, Stepto N, Wu B, Mitchell CA, Tonks NK, Watt MJ, Febbraio MA, Crack PJ, Andrikopoulos S, Tiganis T. Loh K, et al. Among authors: tiganis t. Cell Metab. 2009 Oct;10(4):260-72. doi: 10.1016/j.cmet.2009.08.009. Cell Metab. 2009. PMID: 19808019 Free PMC article.
Silencer of death domains (SODD) inhibits skeletal muscle and kidney enriched inositol 5-phosphatase (SKIP) and regulates phosphoinositide 3-kinase (PI3K)/Akt signaling to the actin cytoskeleton.
Rahman P, Huysmans RD, Wiradjaja F, Gurung R, Ooms LM, Sheffield DA, Dyson JM, Layton MJ, Sriratana A, Takada H, Tiganis T, Mitchell CA. Rahman P, et al. Among authors: tiganis t. J Biol Chem. 2011 Aug 26;286(34):29758-70. doi: 10.1074/jbc.M111.263103. Epub 2011 Jun 28. J Biol Chem. 2011. PMID: 21712384 Free PMC article.
123 results