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Detrimental effects of adenosine signaling in sickle cell disease.
Zhang Y, Dai Y, Wen J, Zhang W, Grenz A, Sun H, Tao L, Lu G, Alexander DC, Milburn MV, Carter-Dawson L, Lewis DE, Zhang W, Eltzschig HK, Kellems RE, Blackburn MR, Juneja HS, Xia Y. Zhang Y, et al. Among authors: zhang w. Nat Med. 2011 Jan;17(1):79-86. doi: 10.1038/nm.2280. Epub 2010 Dec 19. Nat Med. 2011. PMID: 21170046 Free PMC article.
A2B adenosine receptor-mediated induction of IL-6 promotes CKD.
Dai Y, Zhang W, Wen J, Zhang Y, Kellems RE, Xia Y. Dai Y, et al. Among authors: zhang w, zhang y. J Am Soc Nephrol. 2011 May;22(5):890-901. doi: 10.1681/ASN.2010080890. Epub 2011 Apr 21. J Am Soc Nephrol. 2011. PMID: 21511827 Free PMC article.
Af17 deficiency increases sodium excretion and decreases blood pressure.
Chen L, Wu H, Pochynyuk OM, Reisenauer MR, Zhang Z, Huang L, Zaika OL, Mamenko M, Zhang W, Zhou Q, Liu M, Xia Y, Zhang W. Chen L, et al. Among authors: zhang w, zhang z. J Am Soc Nephrol. 2011 Jun;22(6):1076-86. doi: 10.1681/ASN.2010121270. Epub 2011 May 5. J Am Soc Nephrol. 2011. PMID: 21546577 Free PMC article.
Angiotensin receptor agonistic autoantibody-mediated soluble fms-like tyrosine kinase-1 induction contributes to impaired adrenal vasculature and decreased aldosterone production in preeclampsia.
Siddiqui AH, Irani RA, Zhang W, Wang W, Blackwell SC, Kellems RE, Xia Y. Siddiqui AH, et al. Among authors: zhang w. Hypertension. 2013 Feb;61(2):472-9. doi: 10.1161/HYPERTENSIONAHA.111.00157. Epub 2013 Jan 2. Hypertension. 2013. PMID: 23283357 Free PMC article.
Elevated ecto-5'-nucleotidase-mediated increased renal adenosine signaling via A2B adenosine receptor contributes to chronic hypertension.
Zhang W, Zhang Y, Wang W, Dai Y, Ning C, Luo R, Sun K, Glover L, Grenz A, Sun H, Tao L, Zhang W, Colgan SP, Blackburn MR, Eltzschig HK, Kellems RE, Xia Y. Zhang W, et al. Among authors: zhang y. Circ Res. 2013 May 24;112(11):1466-78. doi: 10.1161/CIRCRESAHA.111.300166. Epub 2013 Apr 12. Circ Res. 2013. PMID: 23584256 Free PMC article.
Excess LIGHT contributes to placental impairment, increased secretion of vasoactive factors, hypertension, and proteinuria in preeclampsia.
Wang W, Parchim NF, Iriyama T, Luo R, Zhao C, Liu C, Irani RA, Zhang W, Ning C, Zhang Y, Blackwell SC, Chen L, Tao L, Hicks MJ, Kellems RE, Xia Y. Wang W, et al. Among authors: zhang w, zhang y. Hypertension. 2014 Mar;63(3):595-606. doi: 10.1161/HYPERTENSIONAHA.113.02458. Epub 2013 Dec 9. Hypertension. 2014. PMID: 24324043 Free PMC article.
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