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Inhibition of thioredoxin reductase 1 by porphyrins and other small molecules identified by a high-throughput screening assay.
Free Radic Biol Med. 2011 May 1;50(9):1114-23. doi: 10.1016/j.freeradbiomed.2011.01.020. Epub 2011 Jan 22.
Free Radic Biol Med. 2011.
PMID: 21262347
Free PMC article.
Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy.
Stafford WC, Peng X, Olofsson MH, Zhang X, Luci DK, Lu L, Cheng Q, Trésaugues L, Dexheimer TS, Coussens NP, Augsten M, Ahlzén HM, Orwar O, Östman A, Stone-Elander S, Maloney DJ, Jadhav A, Simeonov A, Linder S, Arnér ESJ.
Stafford WC, et al.
Sci Transl Med. 2018 Feb 14;10(428):eaaf7444. doi: 10.1126/scitranslmed.aaf7444.
Sci Transl Med. 2018.
PMID: 29444979
Free PMC article.
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Redox effects and cytotoxic profiles of MJ25 and auranofin towards malignant melanoma cells.
Sachweh MC, Stafford WC, Drummond CJ, McCarthy AR, Higgins M, Campbell J, Brodin B, Arnér ES, Laín S.
Sachweh MC, et al. Among authors: stafford wc.
Oncotarget. 2015 Jun 30;6(18):16488-506. doi: 10.18632/oncotarget.4108.
Oncotarget. 2015.
PMID: 26029997
Free PMC article.
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Indolin-2-one compounds targeting thioredoxin reductase as potential anticancer drug leads.
Kaminska KK, Bertrand HC, Tajima H, Stafford WC, Cheng Q, Chen W, Wells G, Arner ES, Chew EH.
Kaminska KK, et al. Among authors: stafford wc.
Oncotarget. 2016 Jun 28;7(26):40233-40251. doi: 10.18632/oncotarget.9579.
Oncotarget. 2016.
PMID: 27244886
Free PMC article.
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The 19S Deubiquitinase inhibitor b-AP15 is enriched in cells and elicits rapid commitment to cell death.
Wang X, Stafford W, Mazurkiewicz M, Fryknäs M, Brjnic S, Zhang X, Gullbo J, Larsson R, Arnér ES, D'Arcy P, Linder S.
Wang X, et al.
Mol Pharmacol. 2014 Jun;85(6):932-45. doi: 10.1124/mol.113.091322. Epub 2014 Apr 8.
Mol Pharmacol. 2014.
PMID: 24714215
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