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Recognition of herpesviruses by the innate immune system.
Paludan SR, Bowie AG, Horan KA, Fitzgerald KA. Paludan SR, et al. Among authors: horan ka. Nat Rev Immunol. 2011 Feb;11(2):143-54. doi: 10.1038/nri2937. Nat Rev Immunol. 2011. PMID: 21267015 Free PMC article. Review.
IFI16 is an innate immune sensor for intracellular DNA.
Unterholzner L, Keating SE, Baran M, Horan KA, Jensen SB, Sharma S, Sirois CM, Jin T, Latz E, Xiao TS, Fitzgerald KA, Paludan SR, Bowie AG. Unterholzner L, et al. Among authors: horan ka. Nat Immunol. 2010 Nov;11(11):997-1004. doi: 10.1038/ni.1932. Epub 2010 Oct 3. Nat Immunol. 2010. PMID: 20890285 Free PMC article.
Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING.
Holm CK, Jensen SB, Jakobsen MR, Cheshenko N, Horan KA, Moeller HB, Gonzalez-Dosal R, Rasmussen SB, Christensen MH, Yarovinsky TO, Rixon FJ, Herold BC, Fitzgerald KA, Paludan SR. Holm CK, et al. Among authors: horan ka. Nat Immunol. 2012 Jun 17;13(8):737-43. doi: 10.1038/ni.2350. Nat Immunol. 2012. PMID: 22706339 Free PMC article.
Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors.
Horan KA, Hansen K, Jakobsen MR, Holm CK, Søby S, Unterholzner L, Thompson M, West JA, Iversen MB, Rasmussen SB, Ellermann-Eriksen S, Kurt-Jones E, Landolfo S, Damania B, Melchjorsen J, Bowie AG, Fitzgerald KA, Paludan SR. Horan KA, et al. J Immunol. 2013 Mar 1;190(5):2311-9. doi: 10.4049/jimmunol.1202749. Epub 2013 Jan 23. J Immunol. 2013. PMID: 23345332 Free PMC article.
Evasion of innate cytosolic DNA sensing by a gammaherpesvirus facilitates establishment of latent infection.
Sun C, Schattgen SA, Pisitkun P, Jorgensen JP, Hilterbrand AT, Wang LJ, West JA, Hansen K, Horan KA, Jakobsen MR, O'Hare P, Adler H, Sun R, Ploegh HL, Damania B, Upton JW, Fitzgerald KA, Paludan SR. Sun C, et al. Among authors: horan ka. J Immunol. 2015 Feb 15;194(4):1819-31. doi: 10.4049/jimmunol.1402495. Epub 2015 Jan 16. J Immunol. 2015. PMID: 25595793 Free PMC article.
Extracellular 2'-5' oligoadenylate synthetase stimulates RNase L-independent antiviral activity: a novel mechanism of virus-induced innate immunity.
Kristiansen H, Scherer CA, McVean M, Iadonato SP, Vends S, Thavachelvam K, Steffensen TB, Horan KA, Kuri T, Weber F, Paludan SR, Hartmann R. Kristiansen H, et al. Among authors: horan ka. J Virol. 2010 Nov;84(22):11898-904. doi: 10.1128/JVI.01003-10. Epub 2010 Sep 15. J Virol. 2010. PMID: 20844035 Free PMC article.
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