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PITX2c is expressed in the adult left atrium, and reducing Pitx2c expression promotes atrial fibrillation inducibility and complex changes in gene expression.
Kirchhof P, Kahr PC, Kaese S, Piccini I, Vokshi I, Scheld HH, Rotering H, Fortmueller L, Laakmann S, Verheule S, Schotten U, Fabritz L, Brown NA. Kirchhof P, et al. Among authors: kaese s. Circ Cardiovasc Genet. 2011 Apr;4(2):123-33. doi: 10.1161/CIRCGENETICS.110.958058. Epub 2011 Jan 31. Circ Cardiovasc Genet. 2011. PMID: 21282332
Overexpression of cAMP-response element modulator causes abnormal growth and development of the atrial myocardium resulting in a substrate for sustained atrial fibrillation in mice.
Kirchhof P, Marijon E, Fabritz L, Li N, Wang W, Wang T, Schulte K, Hanstein J, Schulte JS, Vogel M, Mougenot N, Laakmann S, Fortmueller L, Eckstein J, Verheule S, Kaese S, Staab A, Grote-Wessels S, Schotten U, Moubarak G, Wehrens XH, Schmitz W, Hatem S, Müller FU. Kirchhof P, et al. Among authors: kaese s. Int J Cardiol. 2013 Jun 20;166(2):366-74. doi: 10.1016/j.ijcard.2011.10.057. Epub 2011 Nov 16. Int J Cardiol. 2013. PMID: 22093963 Free PMC article.
Knock-in gain-of-function sodium channel mutation prolongs atrial action potentials and alters atrial vulnerability.
Blana A, Kaese S, Fortmüller L, Laakmann S, Damke D, van Bragt K, Eckstein J, Piccini I, Kirchhefer U, Nattel S, Breithardt G, Carmeliet P, Carmeliet E, Schotten U, Verheule S, Kirchhof P, Fabritz L. Blana A, et al. Among authors: kaese s. Heart Rhythm. 2010 Dec;7(12):1862-9. doi: 10.1016/j.hrthm.2010.08.016. Epub 2010 Aug 19. Heart Rhythm. 2010. PMID: 20728579
The ECG in cardiovascular-relevant animal models of electrophysiology.
Kaese S, Frommeyer G, Verheule S, van Loon G, Gehrmann J, Breithardt G, Eckardt L. Kaese S, et al. Herzschrittmacherther Elektrophysiol. 2013 Jun;24(2):84-91. doi: 10.1007/s00399-013-0260-z. Epub 2013 Jun 6. Herzschrittmacherther Elektrophysiol. 2013. PMID: 23740318
Triggered activity in atrial myocytes is influenced by Na+/Ca2+ exchanger activity in genetically altered mice.
Bögeholz N, Pauls P, Kaese S, Schulte JS, Lemoine MD, Dechering DG, Frommeyer G, Goldhaber JI, Seidl MD, Kirchhefer U, Eckardt L, Müller FU, Pott C. Bögeholz N, et al. Among authors: kaese s. J Mol Cell Cardiol. 2016 Dec;101:106-115. doi: 10.1016/j.yjmcc.2016.11.004. Epub 2016 Nov 9. J Mol Cell Cardiol. 2016. PMID: 27838371 Free PMC article.
33 results