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Recombinant ADAMTS13 normalizes von Willebrand factor-cleaving activity in plasma of acquired TTP patients by overriding inhibitory antibodies.
Plaimauer B, Kremer Hovinga JA, Juno C, Wolfsegger MJ, Skalicky S, Schmidt M, Grillberger L, Hasslacher M, Knöbl P, Ehrlich H, Scheiflinger F. Plaimauer B, et al. Among authors: wolfsegger mj. J Thromb Haemost. 2011 May;9(5):936-44. doi: 10.1111/j.1538-7836.2011.04224.x. J Thromb Haemost. 2011. PMID: 21294825 Free article.
Distinct characteristics of antibody responses against factor VIII in healthy individuals and in different cohorts of hemophilia A patients.
Whelan SF, Hofbauer CJ, Horling FM, Allacher P, Wolfsegger MJ, Oldenburg J, Male C, Windyga J, Tiede A, Schwarz HP, Scheiflinger F, Reipert BM. Whelan SF, et al. Among authors: wolfsegger mj. Blood. 2013 Feb 7;121(6):1039-48. doi: 10.1182/blood-2012-07-444877. Epub 2012 Dec 12. Blood. 2013. PMID: 23243272 Free article.
Pharmacokinetics, disease-modifying activity, and safety of an experimental therapeutic targeting an immunological isoform of macrophage migration inhibitory factor, in rat glomerulonephritis.
Höllriegl W, Bauer A, Baumgartner B, Dietrich B, Douillard P, Kerschbaumer RJ, Höbarth G, McKee JS, Schinagl A, Tam FWK, Thiele M, Weber A, Wolfsegger M, Turecek M, Muchitsch EM, Scheiflinger F, Glantschnig H. Höllriegl W, et al. Eur J Pharmacol. 2018 Feb 5;820:206-216. doi: 10.1016/j.ejphar.2017.12.040. Epub 2017 Dec 20. Eur J Pharmacol. 2018. PMID: 29274331 Free article.
Evaluation of Factor VIII Polysialylation: Identification of a Longer-Acting Experimental Therapy in Mice and Monkeys.
Glantschnig H, Bauer A, Benamara K, Dockal M, Ehrlich V, Gritsch H, Höbarth G, Horling FM, Kopic A, Leidenmühler P, Reipert BM, Rottensteiner H, Ruthsatz T, Schrenk G, Schuster M, Turecek PL, Weber A, Wolfsegger M, Scheiflinger F, Höllriegl W. Glantschnig H, et al. J Pharmacol Exp Ther. 2019 Oct;371(1):95-105. doi: 10.1124/jpet.119.260067. Epub 2019 Jul 31. J Pharmacol Exp Ther. 2019. PMID: 31366602
SHP656, a polysialylated recombinant factor VIII (PSA-rFVIII): First-in-human study evaluating safety, tolerability and pharmacokinetics in patients with severe haemophilia A.
Tiede A, Allen G, Bauer A, Chowdary P, Collins P, Goldstein B, Jiang HJ, Kӧck K, Takács I, Timofeeva M, Wolfsegger M, Srivastava S. Tiede A, et al. Haemophilia. 2020 Jan;26(1):47-55. doi: 10.1111/hae.13878. Epub 2019 Nov 28. Haemophilia. 2020. PMID: 31778283 Free PMC article. Clinical Trial.
31 results