Malfait AM - Search Results

1

Knockout of ADAMTS5 does not eliminate cartilage aggrecanase activity but abrogates joint fibrosis and promotes cartilage aggrecan deposition in murine osteoarthritis models.

Li J, Anemaet W, Diaz MA, Buchanan S, Tortorella M, Malfait AM, Mikecz K, Sandy JD, Plaas A. Li J, et al. Among authors: malfait am. J Orthop Res. 2011 Apr;29(4):516-22. doi: 10.1002/jor.21215. Epub 2010 Oct 26. J Orthop Res. 2011. PMID: 21337391 Free article.

2

Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage.

Malfait AM, Liu RQ, Ijiri K, Komiya S, Tortorella MD. Malfait AM, et al. J Biol Chem. 2002 Jun 21;277(25):22201-8. doi: 10.1074/jbc.M200431200. Epub 2002 Apr 15. J Biol Chem. 2002. PMID: 11956193 Free article.

3

The usual suspects: verdict not guilty?

Tortorella MD, Malfait AM. Tortorella MD, et al. Among authors: malfait am. Arthritis Rheum. 2003 Dec;48(12):3304-7. doi: 10.1002/art.11356. Arthritis Rheum. 2003. PMID: 14673981 Free article. Review. No abstract available.

4

Alpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes.

Tortorella MD, Arner EC, Hills R, Easton A, Korte-Sarfaty J, Fok K, Wittwer AJ, Liu RQ, Malfait AM. Tortorella MD, et al. Among authors: malfait am. J Biol Chem. 2004 Apr 23;279(17):17554-61. doi: 10.1074/jbc.M313041200. Epub 2004 Jan 7. J Biol Chem. 2004. PMID: 14715656 Free article.

5

Proprotein convertase furin interacts with and cleaves pro-ADAMTS4 (Aggrecanase-1) in the trans-Golgi network.

Wang P, Tortorella M, England K, Malfait AM, Thomas G, Arner EC, Pei D. Wang P, et al. Among authors: malfait am. J Biol Chem. 2004 Apr 9;279(15):15434-40. doi: 10.1074/jbc.M312797200. Epub 2004 Jan 26. J Biol Chem. 2004. PMID: 14744861 Free article.

6

ADAMTS-4 (aggrecanase-1): N-terminal activation mechanisms.

Tortorella MD, Arner EC, Hills R, Gormley J, Fok K, Pegg L, Munie G, Malfait AM. Tortorella MD, et al. Among authors: malfait am. Arch Biochem Biophys. 2005 Dec 1;444(1):34-44. doi: 10.1016/j.abb.2005.09.018. Epub 2005 Oct 26. Arch Biochem Biophys. 2005. PMID: 16289022

7

Identification of fibronectin neoepitopes present in human osteoarthritic cartilage.

Zack MD, Arner EC, Anglin CP, Alston JT, Malfait AM, Tortorella MD. Zack MD, et al. Among authors: malfait am. Arthritis Rheum. 2006 Sep;54(9):2912-22. doi: 10.1002/art.22045. Arthritis Rheum. 2006. PMID: 16948117 Free article.

8

Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5.

Song RH, Tortorella MD, Malfait AM, Alston JT, Yang Z, Arner EC, Griggs DW. Song RH, et al. Among authors: malfait am. Arthritis Rheum. 2007 Feb;56(2):575-85. doi: 10.1002/art.22334. Arthritis Rheum. 2007. PMID: 17265492 Free article.

9

Substrate-dependent inhibition kinetics of an active site-directed inhibitor of ADAMTS-4 (Aggrecanase 1).

Wittwer AJ, Hills RL, Keith RH, Munie GE, Arner EC, Anglin CP, Malfait AM, Tortorella MD. Wittwer AJ, et al. Among authors: malfait am. Biochemistry. 2007 May 29;46(21):6393-401. doi: 10.1021/bi7000642. Epub 2007 May 8. Biochemistry. 2007. PMID: 17487981

10

High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2).

Shieh HS, Mathis KJ, Williams JM, Hills RL, Wiese JF, Benson TE, Kiefer JR, Marino MH, Carroll JN, Leone JW, Malfait AM, Arner EC, Tortorella MD, Tomasselli A. Shieh HS, et al. Among authors: malfait am. J Biol Chem. 2008 Jan 18;283(3):1501-1507. doi: 10.1074/jbc.M705879200. Epub 2007 Nov 8. J Biol Chem. 2008. PMID: 17991750 Free article.

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