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Design of a novel pyrrolidine scaffold utilized in the discovery of potent and selective human β3 adrenergic receptor agonists.
Bioorg Med Chem Lett. 2011 Mar 15;21(6):1865-70. doi: 10.1016/j.bmcl.2010.12.087. Epub 2010 Dec 25.
Bioorg Med Chem Lett. 2011.
PMID: 21353541
Potentially mutagenic impurities: analysis of structural classes and carcinogenic potencies of chemical intermediates in pharmaceutical syntheses supports alternative methods to the default TTC for calculating safe levels of impurities.
Galloway SM, Vijayaraj Reddy M, McGettigan K, Gealy R, Bercu J.
Galloway SM, et al.
Regul Toxicol Pharmacol. 2013 Aug;66(3):326-35. doi: 10.1016/j.yrtph.2013.05.005. Epub 2013 May 17.
Regul Toxicol Pharmacol. 2013.
PMID: 23688841
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Validation of a flow cytometric in vitro DNA repair (UDS) assay in rat hepatocytes.
Selden JR, Dolbeare F, Clair JH, Miller JE, McGettigan K, DiJohn JA, Dysart GR, DeLuca JG.
Selden JR, et al.
Mutat Res. 1994 Sep;315(2):147-67. doi: 10.1016/0921-8777(94)90015-9.
Mutat Res. 1994.
PMID: 7520997
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