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Design of a novel pyrrolidine scaffold utilized in the discovery of potent and selective human β3 adrenergic receptor agonists.
Morriello GJ, Wendt HR, Bansal A, Di Salvo J, Feighner S, He J, Hurley AL, Hreniuk DL, Salituro GM, Reddy MV, Galloway SM, McGettigan KK, Laws G, McKnight C, Doss GA, Tsou NN, Black RM, Morris J, Ball RG, Sanfiz AT, Streckfuss E, Struthers M, Edmondson SD. Morriello GJ, et al. Among authors: streckfuss e. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1865-70. doi: 10.1016/j.bmcl.2010.12.087. Epub 2010 Dec 25. Bioorg Med Chem Lett. 2011. PMID: 21353541
Heterocyclic acetamide and benzamide derivatives as potent and selective beta3-adrenergic receptor agonists with improved rodent pharmacokinetic profiles.
Goble SD, Wang L, Howell KL, Bansal A, Berger R, Brockunier L, DiSalvo J, Feighner S, Harper B, He J, Hurley A, Hreniuk D, Parmee E, Robbins M, Salituro G, Sanfiz A, Streckfuss E, Watkins E, Weber AE, Struthers M, Edmondson SD. Goble SD, et al. Among authors: streckfuss e. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1895-9. doi: 10.1016/j.bmcl.2010.01.130. Epub 2010 Feb 4. Bioorg Med Chem Lett. 2010. PMID: 20181479
High-throughput purification platform in support of drug discovery.
Liu M, Chen K, Christian D, Fatima T, Pissarnitski N, Streckfuss E, Zhang C, Xia L, Borges S, Shi Z, Vachal P, Tata J, Athanasopoulos J. Liu M, et al. Among authors: streckfuss e. ACS Comb Sci. 2012 Jan 9;14(1):51-9. doi: 10.1021/co200138h. Epub 2011 Nov 2. ACS Comb Sci. 2012. PMID: 22032344
Synthesis of HDAC Inhibitor Libraries via Microscale Workflow.
Dykstra KD, Streckfuss E, Liu M, Liu J, Yu Y, Wang M, Kozlowski JA, Myers RW, Buevich AV, Maletic MM, Vachal P, Krska SW. Dykstra KD, et al. Among authors: streckfuss e. ACS Med Chem Lett. 2021 Feb 8;12(3):337-342. doi: 10.1021/acsmedchemlett.0c00596. eCollection 2021 Mar 11. ACS Med Chem Lett. 2021. PMID: 33738059 Free PMC article.
Photoredox-Catalyzed Hydroxymethylation of Heteroaromatic Bases.
Huff CA, Cohen RD, Dykstra KD, Streckfuss E, DiRocco DA, Krska SW. Huff CA, et al. Among authors: streckfuss e. J Org Chem. 2016 Aug 19;81(16):6980-7. doi: 10.1021/acs.joc.6b00811. Epub 2016 Jun 23. J Org Chem. 2016. PMID: 27315015
13 results