Hakem R - Search Results

1

RIP3 mediates the embryonic lethality of caspase-8-deficient mice.

Kaiser WJ, Upton JW, Long AB, Livingston-Rosanoff D, Daley-Bauer LP, Hakem R, Caspary T, Mocarski ES. Kaiser WJ, et al. Among authors: hakem r. Nature. 2011 Mar 17;471(7338):368-72. doi: 10.1038/nature09857. Epub 2011 Mar 2. Nature. 2011. PMID: 21368762 Free PMC article.

2

The c-FLIPL cleavage product p43FLIP promotes activation of extracellular signal-regulated kinase (ERK), nuclear factor κB (NF-κB), and caspase-8 and T cell survival.

Koenig A, Buskiewicz IA, Fortner KA, Russell JQ, Asaoka T, He YW, Hakem R, Eriksson JE, Budd RC. Koenig A, et al. Among authors: hakem r. J Biol Chem. 2014 Jan 10;289(2):1183-91. doi: 10.1074/jbc.M113.506428. Epub 2013 Nov 25. J Biol Chem. 2014. PMID: 24275659 Free PMC article.

3

Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity.

Woo M, Hakem R, Furlonger C, Hakem A, Duncan GS, Sasaki T, Bouchard D, Lu L, Wu GE, Paige CJ, Mak TW. Woo M, et al. Among authors: hakem a, hakem r. Nat Immunol. 2003 Oct;4(10):1016-22. doi: 10.1038/ni976. Epub 2003 Sep 14. Nat Immunol. 2003. PMID: 12970760

4

Caspase-8 inactivation in T cells increases necroptosis and suppresses autoimmunity in Bim-/- mice.

Bohgaki T, Mozo J, Salmena L, Matysiak-Zablocki E, Bohgaki M, Sanchez O, Strasser A, Hakem A, Hakem R. Bohgaki T, et al. Among authors: hakem a, hakem r. J Cell Biol. 2011 Oct 17;195(2):277-91. doi: 10.1083/jcb.201103053. J Cell Biol. 2011. PMID: 22006951 Free PMC article.

5

Requirement for caspase-8 in NF-kappaB activation by antigen receptor.

Su H, Bidère N, Zheng L, Cubre A, Sakai K, Dale J, Salmena L, Hakem R, Straus S, Lenardo M. Su H, et al. Among authors: hakem r. Science. 2005 Mar 4;307(5714):1465-8. doi: 10.1126/science.1104765. Science. 2005. PMID: 15746428

6

DICER1/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-related macular degeneration.

Kim Y, Tarallo V, Kerur N, Yasuma T, Gelfand BD, Bastos-Carvalho A, Hirano Y, Yasuma R, Mizutani T, Fowler BJ, Li S, Kaneko H, Bogdanovich S, Ambati BK, Hinton DR, Hauswirth WW, Hakem R, Wright C, Ambati J. Kim Y, et al. Among authors: hakem r. Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16082-7. doi: 10.1073/pnas.1403814111. Epub 2014 Oct 27. Proc Natl Acad Sci U S A. 2014. PMID: 25349431 Free PMC article.

7

Caspase-8 deficiency in T cells leads to a lethal lymphoinfiltrative immune disorder.

Salmena L, Hakem R. Salmena L, et al. Among authors: hakem r. J Exp Med. 2005 Sep 19;202(6):727-32. doi: 10.1084/jem.20050683. Epub 2005 Sep 12. J Exp Med. 2005. PMID: 16157684 Free PMC article.

8

Endoplasmic reticulum stress-induced death of mouse embryonic fibroblasts requires the intrinsic pathway of apoptosis.

Masud A, Mohapatra A, Lakhani SA, Ferrandino A, Hakem R, Flavell RA. Masud A, et al. Among authors: hakem r. J Biol Chem. 2007 May 11;282(19):14132-9. doi: 10.1074/jbc.M700077200. Epub 2007 Mar 19. J Biol Chem. 2007. PMID: 17371867 Free article.

9

Perforin-dependent activation-induced cell death acts through caspase 3 but not through caspases 8 or 9.

Chen L, Woo M, Hakem R, Miller RG. Chen L, et al. Among authors: hakem r. Eur J Immunol. 2003 Mar;33(3):769-78. doi: 10.1002/eji.200323783. Eur J Immunol. 2003. PMID: 12616497 Free article.

10

Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity.

Salmena L, Lemmers B, Hakem A, Matysiak-Zablocki E, Murakami K, Au PY, Berry DM, Tamblyn L, Shehabeldin A, Migon E, Wakeham A, Bouchard D, Yeh WC, McGlade JC, Ohashi PS, Hakem R. Salmena L, et al. Among authors: hakem a, hakem r. Genes Dev. 2003 Apr 1;17(7):883-95. doi: 10.1101/gad.1063703. Epub 2003 Mar 21. Genes Dev. 2003. PMID: 12654726 Free PMC article.

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