Prescott A - Search Results

1

Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2.

Deng X, Dzamko N, Prescott A, Davies P, Liu Q, Yang Q, Lee JD, Patricelli MP, Nomanbhoy TK, Alessi DR, Gray NS. Deng X, et al. Among authors: prescott a. Nat Chem Biol. 2011 Apr;7(4):203-5. doi: 10.1038/nchembio.538. Epub 2011 Mar 6. Nat Chem Biol. 2011. PMID: 21378983 Free PMC article.

2

Essential role of PDK1 in regulating cell size and development in mice.

Lawlor MA, Mora A, Ashby PR, Williams MR, Murray-Tait V, Malone L, Prescott AR, Lucocq JM, Alessi DR. Lawlor MA, et al. Among authors: prescott ar. EMBO J. 2002 Jul 15;21(14):3728-38. doi: 10.1093/emboj/cdf387. EMBO J. 2002. PMID: 12110585 Free PMC article.

3

Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1.

Kimber WA, Deak M, Prescott AR, Alessi DR. Kimber WA, et al. Among authors: prescott ar. Biochem J. 2003 Dec 1;376(Pt 2):525-35. doi: 10.1042/BJ20031154. Biochem J. 2003. PMID: 14516276 Free PMC article.

4

MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm.

Boudeau J, Baas AF, Deak M, Morrice NA, Kieloch A, Schutkowski M, Prescott AR, Clevers HC, Alessi DR. Boudeau J, et al. Among authors: prescott ar. EMBO J. 2003 Oct 1;22(19):5102-14. doi: 10.1093/emboj/cdg490. EMBO J. 2003. PMID: 14517248 Free PMC article.

5

WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate.

Vitari AC, Deak M, Collins BJ, Morrice N, Prescott AR, Phelan A, Humphreys S, Alessi DR. Vitari AC, et al. Among authors: prescott ar. Biochem J. 2004 Feb 15;378(Pt 1):257-68. doi: 10.1042/BJ20031692. Biochem J. 2004. PMID: 14611643 Free PMC article.

6

The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation.

McManus EJ, Collins BJ, Ashby PR, Prescott AR, Murray-Tait V, Armit LJ, Arthur JS, Alessi DR. McManus EJ, et al. EMBO J. 2004 May 19;23(10):2071-82. doi: 10.1038/sj.emboj.7600218. Epub 2004 Apr 29. EMBO J. 2004. PMID: 15116068 Free PMC article.

7

Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates.

Komander D, Fairservice A, Deak M, Kular GS, Prescott AR, Peter Downes C, Safrany ST, Alessi DR, van Aalten DM. Komander D, et al. Among authors: prescott ar. EMBO J. 2004 Oct 13;23(20):3918-28. doi: 10.1038/sj.emboj.7600379. Epub 2004 Sep 30. EMBO J. 2004. PMID: 15457207 Free PMC article.

8

14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK.

Al-Hakim AK, Göransson O, Deak M, Toth R, Campbell DG, Morrice NA, Prescott AR, Alessi DR. Al-Hakim AK, et al. Among authors: prescott ar. J Cell Sci. 2005 Dec 1;118(Pt 23):5661-73. doi: 10.1242/jcs.02670. J Cell Sci. 2005. PMID: 16306228

9

Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1.

Sakamoto K, Zarrinpashneh E, Budas GR, Pouleur AC, Dutta A, Prescott AR, Vanoverschelde JL, Ashworth A, Jovanović A, Alessi DR, Bertrand L. Sakamoto K, et al. Among authors: prescott ar. Am J Physiol Endocrinol Metab. 2006 May;290(5):E780-8. doi: 10.1152/ajpendo.00443.2005. Epub 2005 Dec 6. Am J Physiol Endocrinol Metab. 2006. PMID: 16332922 Free PMC article.

10

The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation.

Jaleel M, Villa F, Deak M, Toth R, Prescott AR, Van Aalten DM, Alessi DR. Jaleel M, et al. Biochem J. 2006 Mar 15;394(Pt 3):545-55. doi: 10.1042/BJ20051844. Biochem J. 2006. PMID: 16396636 Free PMC article.

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