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6 results
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The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS).
Bioorg Med Chem Lett. 2011 Apr 15;21(8):2468-71. doi: 10.1016/j.bmcl.2011.02.061. Epub 2011 Feb 18.
Bioorg Med Chem Lett. 2011.
PMID: 21398123
Discovery of potent CRTh2 (DP2) receptor antagonists.
Birkinshaw TN, Teague SJ, Beech C, Bonnert RV, Hill S, Patel A, Reakes S, Sanganee H, Dougall IG, Phillips TT, Salter S, Schmidt J, Arrowsmith EC, Carrillo JJ, Bell FM, Paine SW, Weaver R.
Birkinshaw TN, et al.
Bioorg Med Chem Lett. 2006 Aug 15;16(16):4287-90. doi: 10.1016/j.bmcl.2006.05.062. Epub 2006 Jun 5.
Bioorg Med Chem Lett. 2006.
PMID: 16753296
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From ATP to AZD6140: the discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis.
Springthorpe B, Bailey A, Barton P, Birkinshaw TN, Bonnert RV, Brown RC, Chapman D, Dixon J, Guile SD, Humphries RG, Hunt SF, Ince F, Ingall AH, Kirk IP, Leeson PD, Leff P, Lewis RJ, Martin BP, McGinnity DF, Mortimore MP, Paine SW, Pairaudeau G, Patel A, Rigby AJ, Riley RJ, Teobald BJ, Tomlinson W, Webborn PJ, Willis PA.
Springthorpe B, et al. Among authors: birkinshaw tn.
Bioorg Med Chem Lett. 2007 Nov 1;17(21):6013-8. doi: 10.1016/j.bmcl.2007.07.057. Epub 2007 Aug 19.
Bioorg Med Chem Lett. 2007.
PMID: 17827008
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Antagonists of the P2X(7) receptor. From lead identification to drug development.
Guile SD, Alcaraz L, Birkinshaw TN, Bowers KC, Ebden MR, Furber M, Stocks MJ.
Guile SD, et al. Among authors: birkinshaw tn.
J Med Chem. 2009 May 28;52(10):3123-41. doi: 10.1021/jm801528x.
J Med Chem. 2009.
PMID: 19191585
Review.
No abstract available.
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Iodoetherification as a strategy towards sp3-rich scaffolds for drug discovery.
Barnes L, Birkinshaw TN, Senior AJ, Brügge OS, Lewis W, Argent SP, Moody CJ, Nortcliffe A.
Barnes L, et al. Among authors: birkinshaw tn.
Bioorg Med Chem. 2024 Mar 1;101:117636. doi: 10.1016/j.bmc.2024.117636. Epub 2024 Feb 10.
Bioorg Med Chem. 2024.
PMID: 38354458
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In silico prediction of acyl glucuronide reactivity.
Potter T, Lewis R, Luker T, Bonnert R, Bernstein MA, Birkinshaw TN, Thom S, Wenlock M, Paine S.
Potter T, et al. Among authors: birkinshaw tn.
J Comput Aided Mol Des. 2011 Nov;25(11):997-1005. doi: 10.1007/s10822-011-9479-0. Epub 2011 Oct 26.
J Comput Aided Mol Des. 2011.
PMID: 22042375
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