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The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS).
Bioorg Med Chem Lett. 2011 Apr 15;21(8):2468-71. doi: 10.1016/j.bmcl.2011.02.061. Epub 2011 Feb 18.
Bioorg Med Chem Lett. 2011.
PMID: 21398123
1,2-Dihydro-4-quinazolinamines: potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo.
Tinker AC, Beaton HG, Boughton-Smith N, Cook TR, Cooper SL, Fraser-Rae L, Hallam K, Hamley P, McInally T, Nicholls DJ, Pimm AD, Wallace AV.
Tinker AC, et al.
J Med Chem. 2003 Mar 13;46(6):913-6. doi: 10.1021/jm0255926.
J Med Chem. 2003.
PMID: 12620067
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2-aminopyridines as highly selective inducible nitric oxide synthase inhibitors. Differential binding modes dependent on nitrogen substitution.
Connolly S, Aberg A, Arvai A, Beaton HG, Cheshire DR, Cook AR, Cooper S, Cox D, Hamley P, Mallinder P, Millichip I, Nicholls DJ, Rosenfeld RJ, St-Gallay SA, Tainer J, Tinker AC, Wallace AV.
Connolly S, et al.
J Med Chem. 2004 Jun 3;47(12):3320-3. doi: 10.1021/jm031035n.
J Med Chem. 2004.
PMID: 15163211
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3,4-Dihydro-1-isoquinolinamines: a novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency.
Beaton H, Hamley P, Nicholls DJ, Tinker AC, Wallace AV.
Beaton H, et al.
Bioorg Med Chem Lett. 2001 Apr 23;11(8):1023-6. doi: 10.1016/s0960-894x(01)00119-6.
Bioorg Med Chem Lett. 2001.
PMID: 11327580
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Thienopyridines: nitric oxide synthase inhibitors with potent in vivo activity.
Beaton H, Boughton-Smith N, Hamley P, Ghelani A, Nicholls DJ, Tinker AC, Wallace AV.
Beaton H, et al.
Bioorg Med Chem Lett. 2001 Apr 23;11(8):1027-30. doi: 10.1016/s0960-894x(01)00120-2.
Bioorg Med Chem Lett. 2001.
PMID: 11327581
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Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase.
Garcin ED, Arvai AS, Rosenfeld RJ, Kroeger MD, Crane BR, Andersson G, Andrews G, Hamley PJ, Mallinder PR, Nicholls DJ, St-Gallay SA, Tinker AC, Gensmantel NP, Mete A, Cheshire DR, Connolly S, Stuehr DJ, Aberg A, Wallace AV, Tainer JA, Getzoff ED.
Garcin ED, et al. Among authors: hamley pj.
Nat Chem Biol. 2008 Nov;4(11):700-7. doi: 10.1038/nchembio.115. Epub 2008 Oct 12.
Nat Chem Biol. 2008.
PMID: 18849972
Free PMC article.
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High-throughput purification of single compounds and libraries.
Schaffrath M, von Roedern E, Hamley P, Stilz HU.
Schaffrath M, et al.
J Comb Chem. 2005 Jul-Aug;7(4):546-53. doi: 10.1021/cc0498128.
J Comb Chem. 2005.
PMID: 16004497
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