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The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS).
Bioorg Med Chem Lett. 2011 Apr 15;21(8):2468-71. doi: 10.1016/j.bmcl.2011.02.061. Epub 2011 Feb 18.
Bioorg Med Chem Lett. 2011.
PMID: 21398123
Design of novel and potent cPLA2α inhibitors containing an α-methyl-2-ketothiazole as a metabolically stable serine trap.
Mete A, Andrews G, Bernstein M, Connolly S, Hartopp P, Jackson CG, Lewis R, Martin I, Murray D, Riley R, Robinson DH, Smith GM, Wells E, Withnall WJ.
Mete A, et al. Among authors: hartopp p.
Bioorg Med Chem Lett. 2011 May 15;21(10):3128-33. doi: 10.1016/j.bmcl.2011.03.005. Epub 2011 Mar 6.
Bioorg Med Chem Lett. 2011.
PMID: 21450464
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Design and synthesis of a novel and potent series of inhibitors of cytosolic phospholipase A(2) based on a 1,3-disubstituted propan-2-one skeleton.
Connolly S, Bennion C, Botterell S, Croshaw PJ, Hallam C, Hardy K, Hartopp P, Jackson CG, King SJ, Lawrence L, Mete A, Murray D, Robinson DH, Smith GM, Stein L, Walters I, Wells E, Withnall WJ.
Connolly S, et al. Among authors: hartopp p.
J Med Chem. 2002 Mar 14;45(6):1348-62. doi: 10.1021/jm011050x.
J Med Chem. 2002.
PMID: 11882004
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Synthesis and evaluation of substrate-mimicking cytosolic phospholipase A2 inhibitors--reducing the lipophilicity of the arachidonyl chain isostere.
Walters I, Bennion C, Connolly S, Croshaw PJ, Hardy K, Hartopp P, Jackson CG, King SJ, Lawrence L, Mete A, Murray D, Robinson DH, Stein L, Wells E, John Withnall W.
Walters I, et al. Among authors: hartopp p.
Bioorg Med Chem Lett. 2004 Jul 16;14(14):3645-9. doi: 10.1016/j.bmcl.2004.05.024.
Bioorg Med Chem Lett. 2004.
PMID: 15203135
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