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Heparan sulfate/heparin promotes transthyretin fibrillization through selective binding to a basic motif in the protein.
Noborn F, O'Callaghan P, Hermansson E, Zhang X, Ancsin JB, Damas AM, Dacklin I, Presto J, Johansson J, Saraiva MJ, Lundgren E, Kisilevsky R, Westermark P, Li JP. Noborn F, et al. Among authors: kisilevsky r. Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5584-9. doi: 10.1073/pnas.1101194108. Epub 2011 Mar 21. Proc Natl Acad Sci U S A. 2011. PMID: 21422279 Free PMC article.
The heparin/heparan sulfate-binding site on apo-serum amyloid A. Implications for the therapeutic intervention of amyloidosis.
Ancsin JB, Kisilevsky R. Ancsin JB, et al. Among authors: kisilevsky r. J Biol Chem. 1999 Mar 12;274(11):7172-81. doi: 10.1074/jbc.274.11.7172. J Biol Chem. 1999. PMID: 10066777 Free article.
Our present work provides direct evidence that apoSAA can associate with HS (and heparin) and that the occupation of its binding site by HS, and HS analogs, likely caused the previously reported increase in amyloidogenic conformation (beta-sheet) of apoSAA2 (McCubbin, W. D., Kay, …
Our present work provides direct evidence that apoSAA can associate with HS (and heparin) and that the occupation of its binding site by HS, …
159 results