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Heparan sulfate/heparin promotes transthyretin fibrillization through selective binding to a basic motif in the protein.
Noborn F, O'Callaghan P, Hermansson E, Zhang X, Ancsin JB, Damas AM, Dacklin I, Presto J, Johansson J, Saraiva MJ, Lundgren E, Kisilevsky R, Westermark P, Li JP. Noborn F, et al. Among authors: li jp. Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5584-9. doi: 10.1073/pnas.1101194108. Epub 2011 Mar 21. Proc Natl Acad Sci U S A. 2011. PMID: 21422279 Free PMC article.
Heparan sulfate accumulation with Abeta deposits in Alzheimer's disease and Tg2576 mice is contributed by glial cells.
O'Callaghan P, Sandwall E, Li JP, Yu H, Ravid R, Guan ZZ, van Kuppevelt TH, Nilsson LN, Ingelsson M, Hyman BT, Kalimo H, Lindahl U, Lannfelt L, Zhang X. O'Callaghan P, et al. Among authors: li jp. Brain Pathol. 2008 Oct;18(4):548-61. doi: 10.1111/j.1750-3639.2008.00152.x. Epub 2008 Apr 11. Brain Pathol. 2008. PMID: 18422760 Free PMC article.
1,250 results