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Heparan sulfate/heparin promotes transthyretin fibrillization through selective binding to a basic motif in the protein.
Noborn F, O'Callaghan P, Hermansson E, Zhang X, Ancsin JB, Damas AM, Dacklin I, Presto J, Johansson J, Saraiva MJ, Lundgren E, Kisilevsky R, Westermark P, Li JP. Noborn F, et al. Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5584-9. doi: 10.1073/pnas.1101194108. Epub 2011 Mar 21. Proc Natl Acad Sci U S A. 2011. PMID: 21422279 Free PMC article.
Heparan Sulfate Proteoglycans as Relays of Neuroinflammation.
O'Callaghan P, Zhang X, Li JP. O'Callaghan P, et al. J Histochem Cytochem. 2018 Apr;66(4):305-319. doi: 10.1369/0022155417742147. Epub 2018 Jan 1. J Histochem Cytochem. 2018. PMID: 29290138 Free PMC article. Review.
MicroRNA-24 suppression of N-deacetylase/N-sulfotransferase-1 (NDST1) reduces endothelial cell responsiveness to vascular endothelial growth factor A (VEGFA).
Kasza Z, Fredlund Fuchs P, Tamm C, Eriksson AS, O'Callaghan P, Heindryckx F, Spillmann D, Larsson E, Le Jan S, Eriksson I, Gerwins P, Kjellén L, Kreuger J. Kasza Z, et al. J Biol Chem. 2013 Sep 6;288(36):25956-25963. doi: 10.1074/jbc.M113.484360. Epub 2013 Jul 24. J Biol Chem. 2013. PMID: 23884416 Free PMC article.
127 results