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Single-ascending-dose pharmacokinetics and safety of the novel broad-spectrum antifungal triazole BAL4815 after intravenous infusions (50, 100, and 200 milligrams) and oral administrations (100, 200, and 400 milligrams) of its prodrug, BAL8557, in healthy volunteers.
Schmitt-Hoffmann A, Roos B, Heep M, Schleimer M, Weidekamm E, Brown T, Roehrle M, Beglinger C. Schmitt-Hoffmann A, et al. Among authors: schleimer m. Antimicrob Agents Chemother. 2006 Jan;50(1):279-85. doi: 10.1128/AAC.50.1.279-285.2006. Antimicrob Agents Chemother. 2006. PMID: 16377698 Free PMC article. Clinical Trial.
Investigation of the species-dependent in vitro metabolism of BAL30630 by stable isotope labeling and isotope exchange experiments analyzed by capillary liquid chromatography coupled to mass spectrometry.
Wind M, Grunwald H, Gebhardt K, Illig K, Spickermann J, Nuoffer C, Roussel P, Klauer D, Fullhardt P, Schmitt-Hoffmann A, Schleimer M. Wind M, et al. Among authors: schleimer m. J Chromatogr A. 2009 May 1;1216(18):3946-53. doi: 10.1016/j.chroma.2009.03.022. Epub 2009 Mar 13. J Chromatogr A. 2009. PMID: 19327777
Experiments for a systematic comparison between stable-isotope-(deuterium) labeling and radio-((14)C) labeling for the elucidation of the in vitro metabolic pattern of pharmaceutical drugs.
Grunwald H, Hargreaves P, Gebhardt K, Klauer D, Serafyn A, Schmitt-Hoffmann A, Schleimer M, Schlotterbeck G, Wind M. Grunwald H, et al. Among authors: schleimer m. J Pharm Biomed Anal. 2013 Nov;85:138-44. doi: 10.1016/j.jpba.2013.07.004. Epub 2013 Jul 19. J Pharm Biomed Anal. 2013. PMID: 23933567
Elucidation of the in vitro metabolic profile of stable isotope labeled BAL19403 by accurate mass capillary liquid chromatography/quadrupole time-of-flight mass spectrometry and isotope exchange.
Wind M, Gebhardt K, Grunwald H, Spickermann J, Donzelli M, Kellenberger L, Muller M, Fullhardt P, Schmitt-Hoffmann A, Schleimer M. Wind M, et al. Among authors: schleimer m. Rapid Commun Mass Spectrom. 2007;21(7):1093-9. doi: 10.1002/rcm.2926. Rapid Commun Mass Spectrom. 2007. PMID: 17318924
19 results