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Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery.
Erlanson DA, Arndt JW, Cancilla MT, Cao K, Elling RA, English N, Friedman J, Hansen SK, Hession C, Joseph I, Kumaravel G, Lee WC, Lind KE, McDowell RS, Miatkowski K, Nguyen C, Nguyen TB, Park S, Pathan N, Penny DM, Romanowski MJ, Scott D, Silvian L, Simmons RL, Tangonan BT, Yang W, Sun L. Erlanson DA, et al. Among authors: arndt jw. Bioorg Med Chem Lett. 2011 May 15;21(10):3078-83. doi: 10.1016/j.bmcl.2011.03.032. Epub 2011 Mar 17. Bioorg Med Chem Lett. 2011. PMID: 21459573
Heat shock protein 90: inhibitors in clinical trials.
Biamonte MA, Van de Water R, Arndt JW, Scannevin RH, Perret D, Lee WC. Biamonte MA, et al. Among authors: arndt jw. J Med Chem. 2010 Jan 14;53(1):3-17. doi: 10.1021/jm9004708. J Med Chem. 2010. PMID: 20055425 No abstract available.
EC144 is a potent inhibitor of the heat shock protein 90.
Shi J, Van de Water R, Hong K, Lamer RB, Weichert KW, Sandoval CM, Kasibhatla SR, Boehm MF, Chao J, Lundgren K, Timple N, Lough R, Ibanez G, Boykin C, Burrows FJ, Kehry MR, Yun TJ, Harning EK, Ambrose C, Thompson J, Bixler SA, Dunah A, Snodgrass-Belt P, Arndt J, Enyedy IJ, Li P, Hong VS, McKenzie A, Biamonte MA. Shi J, et al. J Med Chem. 2012 Sep 13;55(17):7786-95. doi: 10.1021/jm300810x. Epub 2012 Aug 31. J Med Chem. 2012. PMID: 22938030
Engineering potent long-acting variants of the Wnt inhibitor DKK2.
Sopko R, Mugford JW, Lehmann A, Shapiro RI, Rushe M, Kulkarni A, Worrall J, Amatucci J, Wen D, Pederson NE, Minesinger BK, Arndt JW, Pepinsky B. Sopko R, et al. Among authors: arndt jw. Protein Eng Des Sel. 2017 May 1;30(5):359-372. doi: 10.1093/protein/gzx007. Protein Eng Des Sel. 2017. PMID: 28180900 Free PMC article.
89 results