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Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery.
Erlanson DA, Arndt JW, Cancilla MT, Cao K, Elling RA, English N, Friedman J, Hansen SK, Hession C, Joseph I, Kumaravel G, Lee WC, Lind KE, McDowell RS, Miatkowski K, Nguyen C, Nguyen TB, Park S, Pathan N, Penny DM, Romanowski MJ, Scott D, Silvian L, Simmons RL, Tangonan BT, Yang W, Sun L. Erlanson DA, et al. Among authors: friedman j. Bioorg Med Chem Lett. 2011 May 15;21(10):3078-83. doi: 10.1016/j.bmcl.2011.03.032. Epub 2011 Mar 17. Bioorg Med Chem Lett. 2011. PMID: 21459573
Small-molecule inhibition of TNF-alpha.
He MM, Smith AS, Oslob JD, Flanagan WM, Braisted AC, Whitty A, Cancilla MT, Wang J, Lugovskoy AA, Yoburn JC, Fung AD, Farrington G, Eldredge JK, Day ES, Cruz LA, Cachero TG, Miller SK, Friedman JE, Choong IC, Cunningham BC. He MM, et al. Among authors: friedman je. Science. 2005 Nov 11;310(5750):1022-5. doi: 10.1126/science.1116304. Science. 2005. PMID: 16284179
A kinase-focused compound collection: compilation and screening strategy.
Sun D, Chuaqui C, Deng Z, Bowes S, Chin D, Singh J, Cullen P, Hankins G, Lee WC, Donnelly J, Friedman J, Josiah S. Sun D, et al. Among authors: friedman j. Chem Biol Drug Des. 2006 Jun;67(6):385-94. doi: 10.1111/j.1747-0285.2006.00396.x. Chem Biol Drug Des. 2006. PMID: 16882313
SM16, an orally active TGF-beta type I receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model.
Fu K, Corbley MJ, Sun L, Friedman JE, Shan F, Papadatos JL, Costa D, Lutterodt F, Sweigard H, Bowes S, Choi M, Boriack-Sjodin PA, Arduini RM, Sun D, Newman MN, Zhang X, Mead JN, Chuaqui CE, Cheung HK, Zhang X, Cornebise M, Carter MB, Josiah S, Singh J, Lee WC, Gill A, Ling LE. Fu K, et al. Among authors: friedman je. Arterioscler Thromb Vasc Biol. 2008 Apr;28(4):665-71. doi: 10.1161/ATVBAHA.107.158030. Epub 2008 Jan 17. Arterioscler Thromb Vasc Biol. 2008. PMID: 18202322
PEARL-seq: A Photoaffinity Platform for the Analysis of Small Molecule-RNA Interactions.
Mukherjee H, Blain JC, Vandivier LE, Chin DN, Friedman JE, Liu F, Maillet A, Fang C, Kaplan JB, Li J, Chenoweth DM, Christensen AB, Petersen LK, Hansen NJV, Barrera L, Kubica N, Kumaravel G, Petter JC. Mukherjee H, et al. Among authors: friedman je. ACS Chem Biol. 2020 Sep 18;15(9):2374-2381. doi: 10.1021/acschembio.0c00357. Epub 2020 Aug 17. ACS Chem Biol. 2020. PMID: 32804474 Free article.
BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90.
Lundgren K, Zhang H, Brekken J, Huser N, Powell RE, Timple N, Busch DJ, Neely L, Sensintaffar JL, Yang YC, McKenzie A, Friedman J, Scannevin R, Kamal A, Hong K, Kasibhatla SR, Boehm MF, Burrows FJ. Lundgren K, et al. Among authors: friedman j. Mol Cancer Ther. 2009 Apr;8(4):921-9. doi: 10.1158/1535-7163.MCT-08-0758. Mol Cancer Ther. 2009. PMID: 19372565
4,022 results