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Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery.
Erlanson DA, Arndt JW, Cancilla MT, Cao K, Elling RA, English N, Friedman J, Hansen SK, Hession C, Joseph I, Kumaravel G, Lee WC, Lind KE, McDowell RS, Miatkowski K, Nguyen C, Nguyen TB, Park S, Pathan N, Penny DM, Romanowski MJ, Scott D, Silvian L, Simmons RL, Tangonan BT, Yang W, Sun L. Erlanson DA, et al. Among authors: penny dm. Bioorg Med Chem Lett. 2011 May 15;21(10):3078-83. doi: 10.1016/j.bmcl.2011.03.032. Epub 2011 Mar 17. Bioorg Med Chem Lett. 2011. PMID: 21459573
Mouse Aurora A: expression in Escherichia coli and purification.
Elling RA, Tangonan BT, Penny DM, Smith JT, Vincent DE, Hansen SK, O'Brien T, Romanowski MJ. Elling RA, et al. Among authors: penny dm. Protein Expr Purif. 2007 Jul;54(1):139-46. doi: 10.1016/j.pep.2007.03.002. Epub 2007 Mar 12. Protein Expr Purif. 2007. PMID: 17434748
Fragment-based discovery of nonpeptidic BACE-1 inhibitors using tethering.
Yang W, Fucini RV, Fahr BT, Randal M, Lind KE, Lam MB, Lu W, Lu Y, Cary DR, Romanowski MJ, Colussi D, Pietrak B, Allison TJ, Munshi SK, Penny DM, Pham P, Sun J, Thomas AE, Wilkinson JM, Jacobs JW, McDowell RS, Ballinger MD. Yang W, et al. Among authors: penny dm. Biochemistry. 2009 Jun 2;48(21):4488-96. doi: 10.1021/bi900017q. Biochemistry. 2009. PMID: 19284778
Generation of novel long-acting globular adiponectin molecules.
Ge H, Xiong Y, Lemon B, Lee KJ, Tang J, Wang P, Weiszmann J, Hawkins N, Laudemann J, Min X, Penny D, Wolfe T, Liu Q, Zhang R, Yeh WC, Shen W, Lindberg R, Wang Z, Sheng J, Li Y. Ge H, et al. J Mol Biol. 2010 May 28;399(1):113-9. doi: 10.1016/j.jmb.2010.03.062. Epub 2010 Apr 9. J Mol Biol. 2010. PMID: 20382165
171 results