Thompson PE - Search Results

1

Identification and development of specific inhibitors for insulin-regulated aminopeptidase as a new class of cognitive enhancers.

Albiston AL, Diwakarla S, Fernando RN, Mountford SJ, Yeatman HR, Morgan B, Pham V, Holien JK, Parker MW, Thompson PE, Chai SY. Albiston AL, et al. Among authors: thompson pe. Br J Pharmacol. 2011 Sep;164(1):37-47. doi: 10.1111/j.1476-5381.2011.01402.x. Br J Pharmacol. 2011. PMID: 21470200 Free PMC article. Review.

2

Development of cognitive enhancers based on inhibition of insulin-regulated aminopeptidase.

Chai SY, Yeatman HR, Parker MW, Ascher DB, Thompson PE, Mulvey HT, Albiston AL. Chai SY, et al. Among authors: thompson pe. BMC Neurosci. 2008 Dec 3;9 Suppl 2(Suppl 2):S14. doi: 10.1186/1471-2202-9-S2-S14. BMC Neurosci. 2008. PMID: 19090987 Free PMC article. Review.

3

Phenylalanine-544 plays a key role in substrate and inhibitor binding by providing a hydrophobic packing point at the active site of insulin-regulated aminopeptidase.

Albiston AL, Pham V, Ye S, Ng L, Lew RA, Thompson PE, Holien JK, Morton CJ, Parker MW, Chai SY. Albiston AL, et al. Among authors: thompson pe. Mol Pharmacol. 2010 Oct;78(4):600-7. doi: 10.1124/mol.110.065458. Epub 2010 Jul 13. Mol Pharmacol. 2010. PMID: 20628006

4

Isoform-selective inhibition of phosphoinositide 3-kinase: identification of a new region of nonconserved amino acids critical for p110α inhibition.

Zheng Z, Amran SI, Thompson PE, Jennings IG. Zheng Z, et al. Among authors: thompson pe. Mol Pharmacol. 2011 Oct;80(4):657-64. doi: 10.1124/mol.111.072546. Epub 2011 Jul 21. Mol Pharmacol. 2011. PMID: 21778304

5

Thiophene inhibitors of PDE4: crystal structures show a second binding mode at the catalytic domain of PDE4D2.

Nankervis JL, Feil SC, Hancock NC, Zheng Z, Ng HL, Morton CJ, Holien JK, Ho PW, Frazzetto MM, Jennings IG, Manallack DT, Martin TJ, Thompson PE, Parker MW. Nankervis JL, et al. Among authors: thompson pe. Bioorg Med Chem Lett. 2011 Dec 1;21(23):7089-93. doi: 10.1016/j.bmcl.2011.09.109. Epub 2011 Oct 5. Bioorg Med Chem Lett. 2011. PMID: 22030030

6

Synthesis, structure-activity relationships and brain uptake of a novel series of benzopyran inhibitors of insulin-regulated aminopeptidase.

Mountford SJ, Albiston AL, Charman WN, Ng L, Holien JK, Parker MW, Nicolazzo JA, Thompson PE, Chai SY. Mountford SJ, et al. Among authors: thompson pe. J Med Chem. 2014 Feb 27;57(4):1368-77. doi: 10.1021/jm401540f. Epub 2014 Feb 7. J Med Chem. 2014. PMID: 24471437

7

Synthetic routes to the Neuropeptide Y Y1 receptor antagonist 1229U91 and related analogues for SAR studies and cell-based imaging.

Mountford SJ, Liu M, Zhang L, Groenen M, Herzog H, Holliday ND, Thompson PE. Mountford SJ, et al. Among authors: thompson pe. Org Biomol Chem. 2014 May 28;12(20):3271-81. doi: 10.1039/c4ob00176a. Epub 2014 Apr 14. Org Biomol Chem. 2014. PMID: 24733083

8

Class II but Not Second Class-Prospects for the Development of Class II PI3K Inhibitors.

Mountford SJ, Zheng Z, Sundaram K, Jennings IG, Hamilton JR, Thompson PE. Mountford SJ, et al. Among authors: thompson pe. ACS Med Chem Lett. 2014 Sep 24;6(1):3-6. doi: 10.1021/ml500354e. eCollection 2015 Jan 8. ACS Med Chem Lett. 2014. PMID: 25589915 Free PMC article.

9

Optically Pure, Structural, and Fluorescent Analogues of a Dimeric Y4 Receptor Agonist Derived by an Olefin Metathesis Approach.

Liu M, Mountford SJ, Richardson RR, Groenen M, Holliday ND, Thompson PE. Liu M, et al. Among authors: thompson pe. J Med Chem. 2016 Jul 14;59(13):6059-69. doi: 10.1021/acs.jmedchem.6b00310. Epub 2016 Jun 28. J Med Chem. 2016. PMID: 27295337

10

Discovery and antiplatelet activity of a selective PI3Kβ inhibitor (MIPS-9922).

Zheng Z, Pinson JA, Mountford SJ, Orive S, Schoenwaelder SM, Shackleford D, Powell A, Nelson EM, Hamilton JR, Jackson SP, Jennings IG, Thompson PE. Zheng Z, et al. Among authors: thompson pe. Eur J Med Chem. 2016 Oct 21;122:339-351. doi: 10.1016/j.ejmech.2016.06.010. Epub 2016 Jun 10. Eur J Med Chem. 2016. PMID: 27387421

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