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Page 1
A common MUC5B promoter polymorphism and pulmonary fibrosis.
Seibold MA, Wise AL, Speer MC, Steele MP, Brown KK, Loyd JE, Fingerlin TE, Zhang W, Gudmundsson G, Groshong SD, Evans CM, Garantziotis S, Adler KB, Dickey BF, du Bois RM, Yang IV, Herron A, Kervitsky D, Talbert JL, Markin C, Park J, Crews AL, Slifer SH, Auerbach S, Roy MG, Lin J, Hennessy CE, Schwarz MI, Schwartz DA. Seibold MA, et al. Among authors: roy mg. N Engl J Med. 2011 Apr 21;364(16):1503-12. doi: 10.1056/NEJMoa1013660. N Engl J Med. 2011. PMID: 21506741 Free PMC article.
Muc5b is required for airway defence.
Roy MG, Livraghi-Butrico A, Fletcher AA, McElwee MM, Evans SE, Boerner RM, Alexander SN, Bellinghausen LK, Song AS, Petrova YM, Tuvim MJ, Adachi R, Romo I, Bordt AS, Bowden MG, Sisson JH, Woodruff PG, Thornton DJ, Rousseau K, De la Garza MM, Moghaddam SJ, Karmouty-Quintana H, Blackburn MR, Drouin SM, Davis CW, Terrell KA, Grubb BR, O'Neal WK, Flores SC, Cota-Gomez A, Lozupone CA, Donnelly JM, Watson AM, Hennessy CE, Keith RC, Yang IV, Barthel L, Henson PM, Janssen WJ, Schwartz DA, Boucher RC, Dickey BF, Evans CM. Roy MG, et al. Nature. 2014 Jan 16;505(7483):412-6. doi: 10.1038/nature12807. Epub 2013 Dec 8. Nature. 2014. PMID: 24317696 Free PMC article.
The polymeric mucin Muc5ac is required for allergic airway hyperreactivity.
Evans CM, Raclawska DS, Ttofali F, Liptzin DR, Fletcher AA, Harper DN, McGing MA, McElwee MM, Williams OW, Sanchez E, Roy MG, Kindrachuk KN, Wynn TA, Eltzschig HK, Blackburn MR, Tuvim MJ, Janssen WJ, Schwartz DA, Dickey BF. Evans CM, et al. Among authors: roy mg. Nat Commun. 2015 Feb 17;6:6281. doi: 10.1038/ncomms7281. Nat Commun. 2015. PMID: 25687754 Free PMC article.
Muc5ac: a critical component mediating the rejection of enteric nematodes.
Hasnain SZ, Evans CM, Roy M, Gallagher AL, Kindrachuk KN, Barron L, Dickey BF, Wilson MS, Wynn TA, Grencis RK, Thornton DJ. Hasnain SZ, et al. J Exp Med. 2011 May 9;208(5):893-900. doi: 10.1084/jem.20102057. Epub 2011 Apr 18. J Exp Med. 2011. PMID: 21502330 Free PMC article.
Central role of Muc5ac expression in mucous metaplasia and its regulation by conserved 5' elements.
Young HW, Williams OW, Chandra D, Bellinghausen LK, Pérez G, Suárez A, Tuvim MJ, Roy MG, Alexander SN, Moghaddam SJ, Adachi R, Blackburn MR, Dickey BF, Evans CM. Young HW, et al. Among authors: roy mg. Am J Respir Cell Mol Biol. 2007 Sep;37(3):273-90. doi: 10.1165/rcmb.2005-0460OC. Epub 2007 Apr 26. Am J Respir Cell Mol Biol. 2007. PMID: 17463395 Free PMC article.
Strain-dependent genomic factors affect allergen-induced airway hyperresponsiveness in mice.
Kelada SN, Wilson MS, Tavarez U, Kubalanza K, Borate B, Whitehead GS, Maruoka S, Roy MG, Olive M, Carpenter DE, Brass DM, Wynn TA, Cook DN, Evans CM, Schwartz DA, Collins FS. Kelada SN, et al. Among authors: roy mg. Am J Respir Cell Mol Biol. 2011 Oct;45(4):817-24. doi: 10.1165/rcmb.2010-0315OC. Epub 2011 Mar 4. Am J Respir Cell Mol Biol. 2011. PMID: 21378263 Free PMC article.
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