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4-Aminothiazolyl analogs of GE2270 A: design, synthesis and evaluation of imidazole analogs.
Bioorg Med Chem Lett. 2011 Jun 1;21(11):3210-5. doi: 10.1016/j.bmcl.2011.04.048. Epub 2011 Apr 21.
Bioorg Med Chem Lett. 2011.
PMID: 21550238
In vitro and in vivo activities of novel, semisynthetic thiopeptide inhibitors of bacterial elongation factor Tu.
Leeds JA, LaMarche MJ, Brewer JT, Bushell SM, Deng G, Dewhurst JM, Dzink-Fox J, Gangl E, Jain A, Lee L, Lilly M, Manni K, Mullin S, Neckermann G, Osborne C, Palestrant D, Patane MA, Raimondi A, Ranjitkar S, Rann EM, Sachdeva M, Shao J, Tiamfook S, Whitehead L, Yu D.
Leeds JA, et al. Among authors: rann em.
Antimicrob Agents Chemother. 2011 Nov;55(11):5277-83. doi: 10.1128/AAC.00582-11. Epub 2011 Aug 8.
Antimicrob Agents Chemother. 2011.
PMID: 21825297
Free PMC article.
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4-Aminothiazolyl analogues of GE2270 A: antibacterial lead finding.
LaMarche MJ, Leeds JA, Dzink-Fox J, Gunderson K, Krastel P, Memmert K, Patane MA, Rann EM, Schmitt E, Tiamfook S, Wang B.
LaMarche MJ, et al. Among authors: rann em.
J Med Chem. 2011 Apr 14;54(7):2517-21. doi: 10.1021/jm101602q. Epub 2011 Mar 15.
J Med Chem. 2011.
PMID: 21405087
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Antibacterial optimization of 4-aminothiazolyl analogues of the natural product GE2270 A: identification of the cycloalkylcarboxylic acids.
LaMarche MJ, Leeds JA, Amaral K, Brewer JT, Bushell SM, Dewhurst JM, Dzink-Fox J, Gangl E, Goldovitz J, Jain A, Mullin S, Neckermann G, Osborne C, Palestrant D, Patane MA, Rann EM, Sachdeva M, Shao J, Tiamfook S, Whitehead L, Yu D.
LaMarche MJ, et al. Among authors: rann em.
J Med Chem. 2011 Dec 8;54(23):8099-109. doi: 10.1021/jm200938f. Epub 2011 Nov 1.
J Med Chem. 2011.
PMID: 21999529
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Discovery of LFF571: an investigational agent for Clostridium difficile infection.
LaMarche MJ, Leeds JA, Amaral A, Brewer JT, Bushell SM, Deng G, Dewhurst JM, Ding J, Dzink-Fox J, Gamber G, Jain A, Lee K, Lee L, Lister T, McKenney D, Mullin S, Osborne C, Palestrant D, Patane MA, Rann EM, Sachdeva M, Shao J, Tiamfook S, Trzasko A, Whitehead L, Yifru A, Yu D, Yan W, Zhu Q.
LaMarche MJ, et al. Among authors: rann em.
J Med Chem. 2012 Mar 8;55(5):2376-87. doi: 10.1021/jm201685h. Epub 2012 Feb 23.
J Med Chem. 2012.
PMID: 22315981
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Antibiotic optimization and chemical structure stabilization of thiomuracin A.
LaMarche MJ, Leeds JA, Dzink-Fox J, Gangl E, Krastel P, Neckermann G, Palestrant D, Patane MA, Rann EM, Tiamfook S, Yu D.
LaMarche MJ, et al. Among authors: rann em.
J Med Chem. 2012 Aug 9;55(15):6934-41. doi: 10.1021/jm300783c. Epub 2012 Jul 31.
J Med Chem. 2012.
PMID: 22812377
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Antibacterial and Solubility Optimization of Thiomuracin A.
LaMarche MJ, Leeds JA, Brewer J, Dean K, Ding J, Dzink-Fox J, Gamber G, Jain A, Kerrigan R, Krastel P, Lee K, Lombardo F, McKenney D, Neckermann G, Osborne C, Palestrant D, Patane MA, Rann EM, Robinson Z, Schmitt E, Stams T, Tiamfook S, Yu D, Whitehead L.
LaMarche MJ, et al. Among authors: rann em.
J Med Chem. 2016 Jul 28;59(14):6920-8. doi: 10.1021/acs.jmedchem.6b00726. Epub 2016 Jul 12.
J Med Chem. 2016.
PMID: 27355833
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