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Impact of electrostatics in redox modulation of oxidative stress by Mn porphyrins: protection of SOD-deficient Escherichia coli via alternative mechanism where Mn porphyrin acts as a Mn carrier.
Rebouças JS, DeFreitas-Silva G, Spasojević I, Idemori YM, Benov L, Batinić-Haberle I. Rebouças JS, et al. Free Radic Biol Med. 2008 Jul 15;45(2):201-10. doi: 10.1016/j.freeradbiomed.2008.04.009. Epub 2008 May 5. Free Radic Biol Med. 2008. PMID: 18457677 Free PMC article.
Lipophilicity is a critical parameter that dominates the efficacy of metalloporphyrins in blocking the development of morphine antinociceptive tolerance through peroxynitrite-mediated pathways.
Batinić-Haberle I, Ndengele MM, Cuzzocrea S, Rebouças JS, Spasojević I, Salvemini D. Batinić-Haberle I, et al. Among authors: reboucas js. Free Radic Biol Med. 2009 Jan 15;46(2):212-9. doi: 10.1016/j.freeradbiomed.2008.09.037. Epub 2008 Oct 17. Free Radic Biol Med. 2009. PMID: 18983908 Free PMC article.
Pure MnTBAP selectively scavenges peroxynitrite over superoxide: comparison of pure and commercial MnTBAP samples to MnTE-2-PyP in two models of oxidative stress injury, an SOD-specific Escherichia coli model and carrageenan-induced pleurisy.
Batinić-Haberle I, Cuzzocrea S, Rebouças JS, Ferrer-Sueta G, Mazzon E, Di Paola R, Radi R, Spasojević I, Benov L, Salvemini D. Batinić-Haberle I, et al. Among authors: reboucas js. Free Radic Biol Med. 2009 Jan 15;46(2):192-201. doi: 10.1016/j.freeradbiomed.2008.09.042. Epub 2008 Nov 1. Free Radic Biol Med. 2009. PMID: 19007878 Free PMC article.
High lipophilicity of meta Mn(III) N-alkylpyridylporphyrin-based superoxide dismutase mimics compensates for their lower antioxidant potency and makes them as effective as ortho analogues in protecting superoxide dismutase-deficient Escherichia coli.
Kos I, Benov L, Spasojević I, Rebouças JS, Batinić-Haberle I. Kos I, et al. Among authors: reboucas js. J Med Chem. 2009 Dec 10;52(23):7868-72. doi: 10.1021/jm900576g. J Med Chem. 2009. PMID: 19954250 Free PMC article.
58 results