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Molecular mechanism of the E99K mutation in cardiac actin (ACTC Gene) that causes apical hypertrophy in man and mouse.
Song W, Dyer E, Stuckey DJ, Copeland O, Leung MC, Bayliss C, Messer A, Wilkinson R, Tremoleda JL, Schneider MD, Harding SE, Redwood CS, Clarke K, Nowak K, Monserrat L, Wells D, Marston SB. Song W, et al. Among authors: harding se. J Biol Chem. 2011 Aug 5;286(31):27582-93. doi: 10.1074/jbc.M111.252320. Epub 2011 May 26. J Biol Chem. 2011. PMID: 21622575 Free PMC article.
Systemic autoimmunity induced by the TLR7/8 agonist Resiquimod causes myocarditis and dilated cardiomyopathy in a new mouse model of autoimmune heart disease.
Hasham MG, Baxan N, Stuckey DJ, Branca J, Perkins B, Dent O, Duffy T, Hameed TS, Stella SE, Bellahcene M, Schneider MD, Harding SE, Rosenthal N, Sattler S. Hasham MG, et al. Among authors: harding se. Dis Model Mech. 2017 Mar 1;10(3):259-270. doi: 10.1242/dmm.027409. Dis Model Mech. 2017. PMID: 28250051 Free PMC article.
Isogenic Pairs of hiPSC-CMs with Hypertrophic Cardiomyopathy/LVNC-Associated ACTC1 E99K Mutation Unveil Differential Functional Deficits.
Smith JGW, Owen T, Bhagwan JR, Mosqueira D, Scott E, Mannhardt I, Patel A, Barriales-Villa R, Monserrat L, Hansen A, Eschenhagen T, Harding SE, Marston S, Denning C. Smith JGW, et al. Among authors: harding se. Stem Cell Reports. 2018 Nov 13;11(5):1226-1243. doi: 10.1016/j.stemcr.2018.10.006. Epub 2018 Nov 1. Stem Cell Reports. 2018. PMID: 30392975 Free PMC article.
Computational modeling of Takotsubo cardiomyopathy: effect of spatially varying β-adrenergic stimulation in the rat left ventricle.
Land S, Niederer SA, Louch WE, Røe ÅT, Aronsen JM, Stuckey DJ, Sikkel MB, Tranter MH, Lyon AR, Harding SE, Smith NP. Land S, et al. Among authors: harding se. Am J Physiol Heart Circ Physiol. 2014 Nov 15;307(10):H1487-96. doi: 10.1152/ajpheart.00443.2014. Epub 2014 Sep 19. Am J Physiol Heart Circ Physiol. 2014. PMID: 25239804 Free PMC article.
MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo.
Fiedler LR, Chapman K, Xie M, Maifoshie E, Jenkins M, Golforoush PA, Bellahcene M, Noseda M, Faust D, Jarvis A, Newton G, Paiva MA, Harada M, Stuckey DJ, Song W, Habib J, Narasimhan P, Aqil R, Sanmugalingam D, Yan R, Pavanello L, Sano M, Wang SC, Sampson RD, Kanayaganam S, Taffet GE, Michael LH, Entman ML, Tan TH, Harding SE, Low CMR, Tralau-Stewart C, Perrior T, Schneider MD. Fiedler LR, et al. Among authors: harding se. Cell Stem Cell. 2019 Apr 4;24(4):579-591.e12. doi: 10.1016/j.stem.2019.01.013. Epub 2019 Mar 7. Cell Stem Cell. 2019. PMID: 30853557 Free PMC article.
497 results