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Optimization of the in vitro cardiac safety of hydroxamate-based histone deacetylase inhibitors.
Shultz MD, Cao X, Chen CH, Cho YS, Davis NR, Eckman J, Fan J, Fekete A, Firestone B, Flynn J, Green J, Growney JD, Holmqvist M, Hsu M, Jansson D, Jiang L, Kwon P, Liu G, Lombardo F, Lu Q, Majumdar D, Meta C, Perez L, Pu M, Ramsey T, Remiszewski S, Skolnik S, Traebert M, Urban L, Uttamsingh V, Wang P, Whitebread S, Whitehead L, Yan-Neale Y, Yao YM, Zhou L, Atadja P. Shultz MD, et al. Among authors: whitebread s. J Med Chem. 2011 Jul 14;54(13):4752-72. doi: 10.1021/jm200388e. Epub 2011 Jun 17. J Med Chem. 2011. PMID: 21650221
In vitro safety pharmacology profiling: what else beyond hERG?
Hamon J, Whitebread S, Techer-Etienne V, Le Coq H, Azzaoui K, Urban L. Hamon J, et al. Among authors: whitebread s. Future Med Chem. 2009 Jul;1(4):645-65. doi: 10.4155/fmc.09.51. Future Med Chem. 2009. PMID: 21426031 Review.
Implications of Dynamic Occupancy, Binding Kinetics, and Channel Gating Kinetics for hERG Blocker Safety Assessment and Mitigation.
Pearlstein RA, MacCannell KA, Erdemli G, Yeola S, Helmlinger G, Hu QY, Farid R, Egan W, Whitebread S, Springer C, Beck J, Wang HR, Maciejewski M, Urban L, Duca JS. Pearlstein RA, et al. Among authors: whitebread s. Curr Top Med Chem. 2016;16(16):1792-818. doi: 10.2174/1568026616666160315142156. Curr Top Med Chem. 2016. PMID: 26975508 Review.
Mapping adverse drug reactions in chemical space.
Scheiber J, Jenkins JL, Sukuru SC, Bender A, Mikhailov D, Milik M, Azzaoui K, Whitebread S, Hamon J, Urban L, Glick M, Davies JW. Scheiber J, et al. Among authors: whitebread s. J Med Chem. 2009 May 14;52(9):3103-7. doi: 10.1021/jm801546k. J Med Chem. 2009. PMID: 19378990
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
Reck F, Bermingham A, Blais J, Capka V, Cariaga T, Casarez A, Colvin R, Dean CR, Fekete A, Gong W, Growcott E, Guo H, Jones AK, Li C, Li F, Lin X, Lindvall M, Lopez S, McKenney D, Metzger L, Moser HE, Prathapam R, Rasper D, Rudewicz P, Sethuraman V, Shen X, Shaul J, Simmons RL, Tashiro K, Tang D, Tjandra M, Turner N, Uehara T, Vitt C, Whitebread S, Yifru A, Zang X, Zhu Q. Reck F, et al. Among authors: whitebread s. Bioorg Med Chem Lett. 2018 Feb 15;28(4):748-755. doi: 10.1016/j.bmcl.2018.01.006. Epub 2018 Jan 4. Bioorg Med Chem Lett. 2018. PMID: 29336873
ABP688, a novel selective and high affinity ligand for the labeling of mGlu5 receptors: identification, in vitro pharmacology, pharmacokinetic and biodistribution studies.
Hintermann S, Vranesic I, Allgeier H, Brülisauer A, Hoyer D, Lemaire M, Moenius T, Urwyler S, Whitebread S, Gasparini F, Auberson YP. Hintermann S, et al. Among authors: whitebread s. Bioorg Med Chem. 2007 Jan 15;15(2):903-14. doi: 10.1016/j.bmc.2006.10.038. Epub 2006 Oct 21. Bioorg Med Chem. 2007. PMID: 17110115
61 results