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Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing.
Aging Cell. 2011 Oct;10(5):868-78. doi: 10.1111/j.1474-9726.2011.00726.x. Epub 2011 Jul 19.
Aging Cell. 2011.
PMID: 21668623
Free PMC article.
Towards a gene expression biomarker set for human biological age.
Holly AC, Melzer D, Pilling LC, Henley W, Hernandez DG, Singleton AB, Bandinelli S, Guralnik JM, Ferrucci L, Harries LW.
Holly AC, et al.
Aging Cell. 2013 Apr;12(2):324-6. doi: 10.1111/acel.12044. Epub 2013 Jan 30.
Aging Cell. 2013.
PMID: 23311345
Free PMC article.
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Changes in splicing factor expression are associated with advancing age in man.
Holly AC, Melzer D, Pilling LC, Fellows AC, Tanaka T, Ferrucci L, Harries LW.
Holly AC, et al.
Mech Ageing Dev. 2013 Sep;134(9):356-66. doi: 10.1016/j.mad.2013.05.006. Epub 2013 Jun 6.
Mech Ageing Dev. 2013.
PMID: 23747814
Free PMC article.
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Splicing factor 3B1 hypomethylation is associated with altered SF3B1 transcript expression in older humans.
Holly AC, Pilling LC, Hernandez D, Lee BP, Singleton A, Ferrucci L, Melzer D, Harries LW.
Holly AC, et al.
Mech Ageing Dev. 2014 Jan;135:50-6. doi: 10.1016/j.mad.2014.01.005. Epub 2014 Jan 23.
Mech Ageing Dev. 2014.
PMID: 24463145
Free PMC article.
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Comparison of senescence-associated miRNAs in primary skin and lung fibroblasts.
Holly AC, Grellscheid S, van de Walle P, Dolan D, Pilling LC, Daniels DJ, von Zglinicki T, Ferrucci L, Melzer D, Harries LW.
Holly AC, et al.
Biogerontology. 2015 Aug;16(4):423-34. doi: 10.1007/s10522-015-9560-5. Epub 2015 Feb 21.
Biogerontology. 2015.
PMID: 25700689
Free PMC article.
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Connecting the speckles: Splicing kinases and their role in tumorigenesis and treatment response.
Corkery DP, Holly AC, Lahsaee S, Dellaire G.
Corkery DP, et al. Among authors: holly ac.
Nucleus. 2015;6(4):279-88. doi: 10.1080/19491034.2015.1062194. Epub 2015 Jun 22.
Nucleus. 2015.
PMID: 26098145
Free PMC article.
Review.
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Estrogen receptor alpha (ESR1)-signaling regulates the expression of the taxane-response biomarker PRP4K.
Lahsaee S, Corkery DP, Anthes LE, Holly A, Dellaire G.
Lahsaee S, et al.
Exp Cell Res. 2016 Jan 1;340(1):125-31. doi: 10.1016/j.yexcr.2015.12.013. Epub 2015 Dec 19.
Exp Cell Res. 2016.
PMID: 26712520
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Enzalutamide inhibits testosterone-induced growth of human prostate cancer xenografts in zebrafish and can induce bradycardia.
Melong N, Steele S, MacDonald M, Holly A, Collins CC, Zoubeidi A, Berman JN, Dellaire G.
Melong N, et al.
Sci Rep. 2017 Oct 31;7(1):14698. doi: 10.1038/s41598-017-14413-w.
Sci Rep. 2017.
PMID: 29089623
Free PMC article.
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