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Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing.
Harries LW, Hernandez D, Henley W, Wood AR, Holly AC, Bradley-Smith RM, Yaghootkar H, Dutta A, Murray A, Frayling TM, Guralnik JM, Bandinelli S, Singleton A, Ferrucci L, Melzer D. Harries LW, et al. Among authors: murray a. Aging Cell. 2011 Oct;10(5):868-78. doi: 10.1111/j.1474-9726.2011.00726.x. Epub 2011 Jul 19. Aging Cell. 2011. PMID: 21668623 Free PMC article.
An interleukin-18 polymorphism is associated with reduced serum concentrations and better physical functioning in older people.
Frayling TM, Rafiq S, Murray A, Hurst AJ, Weedon MN, Henley W, Bandinelli S, Corsi AM, Ferrucci L, Guralnik JM, Wallace RB, Melzer D. Frayling TM, et al. Among authors: murray a. J Gerontol A Biol Sci Med Sci. 2007 Jan;62(1):73-8. doi: 10.1093/gerona/62.1.73. J Gerontol A Biol Sci Med Sci. 2007. PMID: 17301041 Free PMC article.
A common variant of the p16(INK4a) genetic region is associated with physical function in older people.
Melzer D, Frayling TM, Murray A, Hurst AJ, Harries LW, Song H, Khaw K, Luben R, Surtees PG, Bandinelli SS, Corsi AM, Ferrucci L, Guralnik JM, Wallace RB, Hattersley AT, Pharoah PD. Melzer D, et al. Among authors: murray a. Mech Ageing Dev. 2007 May-Jun;128(5-6):370-7. doi: 10.1016/j.mad.2007.03.005. Epub 2007 Mar 27. Mech Ageing Dev. 2007. PMID: 17459456 Free PMC article.
A genome-wide association study identifies protein quantitative trait loci (pQTLs).
Melzer D, Perry JR, Hernandez D, Corsi AM, Stevens K, Rafferty I, Lauretani F, Murray A, Gibbs JR, Paolisso G, Rafiq S, Simon-Sanchez J, Lango H, Scholz S, Weedon MN, Arepalli S, Rice N, Washecka N, Hurst A, Britton A, Henley W, van de Leemput J, Li R, Newman AB, Tranah G, Harris T, Panicker V, Dayan C, Bennett A, McCarthy MI, Ruokonen A, Jarvelin MR, Guralnik J, Bandinelli S, Frayling TM, Singleton A, Ferrucci L. Melzer D, et al. Among authors: murray a. PLoS Genet. 2008 May 9;4(5):e1000072. doi: 10.1371/journal.pgen.1000072. PLoS Genet. 2008. PMID: 18464913 Free PMC article.
Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of association.
Wood AR, Hernandez DG, Nalls MA, Yaghootkar H, Gibbs JR, Harries LW, Chong S, Moore M, Weedon MN, Guralnik JM, Bandinelli S, Murray A, Ferrucci L, Singleton AB, Melzer D, Frayling TM. Wood AR, et al. Among authors: murray a. Hum Mol Genet. 2011 Oct 15;20(20):4082-92. doi: 10.1093/hmg/ddr328. Epub 2011 Jul 28. Hum Mol Genet. 2011. PMID: 21798870 Free PMC article.
3,753 results