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Huntingtin-interacting protein 14 is a type 1 diabetes candidate protein regulating insulin secretion and beta-cell apoptosis.
Berchtold LA, Størling ZM, Ortis F, Lage K, Bang-Berthelsen C, Bergholdt R, Hald J, Brorsson CA, Eizirik DL, Pociot F, Brunak S, Størling J. Berchtold LA, et al. Among authors: eizirik dl. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):E681-8. doi: 10.1073/pnas.1104384108. Epub 2011 Jun 24. Proc Natl Acad Sci U S A. 2011. PMID: 21705657 Free PMC article.
Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways.
Karlsen AE, Heding PE, Frobøse H, Rønn SG, Kruhøffer M, Orntoft TF, Darville M, Eizirik DL, Pociot F, Nerup J, Mandrup-Poulsen T, Billestrup N. Karlsen AE, et al. Among authors: eizirik dl. Diabetologia. 2004 Nov;47(11):1998-2011. doi: 10.1007/s00125-004-1568-3. Epub 2004 Dec 2. Diabetologia. 2004. PMID: 15578154
Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells.
Cardozo AK, Ortis F, Storling J, Feng YM, Rasschaert J, Tonnesen M, Van Eylen F, Mandrup-Poulsen T, Herchuelz A, Eizirik DL. Cardozo AK, et al. Among authors: eizirik dl. Diabetes. 2005 Feb;54(2):452-61. doi: 10.2337/diabetes.54.2.452. Diabetes. 2005. PMID: 15677503
Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis.
Cnop M, Ladriere L, Hekerman P, Ortis F, Cardozo AK, Dogusan Z, Flamez D, Boyce M, Yuan J, Eizirik DL. Cnop M, et al. Among authors: eizirik dl. J Biol Chem. 2007 Feb 9;282(6):3989-97. doi: 10.1074/jbc.M607627200. Epub 2006 Dec 8. J Biol Chem. 2007. PMID: 17158450 Free article.
Proteomics analysis of cytokine-induced dysfunction and death in insulin-producing INS-1E cells: new insights into the pathways involved.
D'Hertog W, Overbergh L, Lage K, Ferreira GB, Maris M, Gysemans C, Flamez D, Cardozo AK, Van den Bergh G, Schoofs L, Arckens L, Moreau Y, Hansen DA, Eizirik DL, Waelkens E, Mathieu C. D'Hertog W, et al. Among authors: eizirik dl. Mol Cell Proteomics. 2007 Dec;6(12):2180-99. doi: 10.1074/mcp.M700085-MCP200. Epub 2007 Oct 5. Mol Cell Proteomics. 2007. PMID: 17921177 Free article.
419 results