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Balance of Irgm protein activities determines IFN-gamma-induced host defense.
Henry SC, Daniell XG, Burroughs AR, Indaram M, Howell DN, Coers J, Starnbach MN, Hunn JP, Howard JC, Feng CG, Sher A, Taylor GA. Henry SC, et al. Among authors: hunn jp. J Leukoc Biol. 2009 May;85(5):877-85. doi: 10.1189/jlb.1008599. Epub 2009 Jan 27. J Leukoc Biol. 2009. PMID: 19176402 Free PMC article.
Loss of the interferon-γ-inducible regulatory immunity-related GTPase (IRG), Irgm1, causes activation of effector IRG proteins on lysosomes, damaging lysosomal function and predicting the dramatic susceptibility of Irgm1-deficient mice to infection.
Maric-Biresev J, Hunn JP, Krut O, Helms JB, Martens S, Howard JC. Maric-Biresev J, et al. Among authors: hunn jp. BMC Biol. 2016 Apr 20;14:33. doi: 10.1186/s12915-016-0255-4. BMC Biol. 2016. PMID: 27098192 Free PMC article.
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