Heinig R - Search Results

1

Prediction of a potentially effective dose in humans for BAY 60-5521, a potent inhibitor of cholesteryl ester transfer protein (CETP) by allometric species scaling and combined pharmacodynamic and physiologically-based pharmacokinetic modelling.

Weber O, Willmann S, Bischoff H, Li V, Vakalopoulos A, Lustig K, Hafner FT, Heinig R, Schmeck C, Buehner K. Weber O, et al. Among authors: heinig r. Br J Clin Pharmacol. 2012 Feb;73(2):219-31. doi: 10.1111/j.1365-2125.2011.04064.x. Br J Clin Pharmacol. 2012. PMID: 21762205 Free PMC article.

2

Effect of BAY x 7195, an oral receptor antagonist of cysteinyl-leukotrienes, on leukotriene D4-induced bronchoconstriction in normal volunteers.

Wensing G, Heinig R, Priesnitz M, Kuhlmann J. Wensing G, et al. Among authors: heinig r. Eur J Clin Pharmacol. 1994;47(3):227-30. doi: 10.1007/BF02570502. Eur J Clin Pharmacol. 1994. PMID: 7867675 Clinical Trial.

3

Pharmacokinetics, safety and tolerability of the orally administered receptor antagonist of cysteinyl-leukotrienes BAY x 7195 in single-dose escalation studies.

Heinig R, Schaefer HG, Wensing G, Kuhlmann J. Heinig R, et al. Int J Clin Pharmacol Ther. 1995 Oct;33(10):573-9. Int J Clin Pharmacol Ther. 1995. PMID: 8574510 Clinical Trial.

4

Pharmacodynamics and pharmacokinetics of BAY x 7195 aerosol, a new and selective receptor antagonist of cysteinyl-leukotrienes, in normal volunteers.

Wensing G, Heinig R, Kuhlmann J. Wensing G, et al. Among authors: heinig r. Br J Clin Pharmacol. 1996 Aug;42(2):171-8. doi: 10.1046/j.1365-2125.1996.03505.x. Br J Clin Pharmacol. 1996. PMID: 8864314 Free PMC article. Clinical Trial.

5

Pharmacokinetic-pharmacodynamic modelling as a tool to evaluate the clinical relevance of a drug-food interaction for a nisoldipine controlled-release dosage form.

Schaefer HG, Heinig R, Ahr G, Adelmann H, Tetzloff W, Kuhlmann J. Schaefer HG, et al. Among authors: heinig r. Eur J Clin Pharmacol. 1997;51(6):473-80. doi: 10.1007/s002280050233. Eur J Clin Pharmacol. 1997. PMID: 9112062 Clinical Trial.

6

The effect of food and time of administration on the pharmacokinetic and pharmacodynamic profile of metrifonate.

Heinig R, Sachse R. Heinig R, et al. Int J Clin Pharmacol Ther. 1999 Sep;37(9):456-64. Int J Clin Pharmacol Ther. 1999. PMID: 10507245 Clinical Trial.

7

Simultaneous administration of vardenafil and alcohol does not result in a pharmacodynamic or pharmacokinetic interaction in healthy male subjects.

Wensing G, Bauer R, Unger S, Rohde G, Heinig R. Wensing G, et al. Among authors: heinig r. Int J Clin Pharmacol Ther. 2006 May;44(5):216-24. doi: 10.5414/cpp44216. Int J Clin Pharmacol Ther. 2006. PMID: 16724576 Clinical Trial.

8

Single dose pharmacokinetics, pharmacodynamics, tolerability and safety of BAY 60-5521, a potent inhibitor of cholesteryl ester transfer protein.

Boettcher MF, Heinig R, Schmeck C, Kohlsdorfer C, Ludwig M, Schaefer A, Gelfert-Peukert S, Wensing G, Weber O. Boettcher MF, et al. Among authors: heinig r. Br J Clin Pharmacol. 2012 Feb;73(2):210-8. doi: 10.1111/j.1365-2125.2011.04083.x. Br J Clin Pharmacol. 2012. PMID: 21838789 Free PMC article. Clinical Trial.

9

Pharmacokinetics, safety and tolerability of the novel, selective mineralocorticoid receptor antagonist finerenone - results from first-in-man and relative bioavailability studies.

Lentini S, Heinig R, Kimmeskamp-Kirschbaum N, Wensing G. Lentini S, et al. Among authors: heinig r. Fundam Clin Pharmacol. 2016 Apr;30(2):172-84. doi: 10.1111/fcp.12170. Epub 2016 Jan 14. Fundam Clin Pharmacol. 2016. PMID: 26604072

10

Population Pharmacokinetic and Exposure-Response Analysis of Finerenone: Insights Based on Phase IIb Data and Simulations to Support Dose Selection for Pivotal Trials in Type 2 Diabetes with Chronic Kidney Disease.

Snelder N, Heinig R, Drenth HJ, Joseph A, Kolkhof P, Lippert J, Garmann D, Ploeger B, Eissing T. Snelder N, et al. Among authors: heinig r. Clin Pharmacokinet. 2020 Mar;59(3):359-370. doi: 10.1007/s40262-019-00820-x. Clin Pharmacokinet. 2020. PMID: 31583611 Free PMC article. Clinical Trial.

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