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Results of a phase II trial of gemcitabine plus doxorubicin in patients with recurrent head and neck cancers: serum C₁₈-ceramide as a novel biomarker for monitoring response.
Saddoughi SA, Garrett-Mayer E, Chaudhary U, O'Brien PE, Afrin LB, Day TA, Gillespie MB, Sharma AK, Wilhoit CS, Bostick R, Senkal CE, Hannun YA, Bielawski J, Simon GR, Shirai K, Ogretmen B. Saddoughi SA, et al. Among authors: bielawski j. Clin Cancer Res. 2011 Sep 15;17(18):6097-105. doi: 10.1158/1078-0432.CCR-11-0930. Epub 2011 Jul 26. Clin Cancer Res. 2011. PMID: 21791630 Free PMC article. Clinical Trial.
Potent antitumor activity of a novel cationic pyridinium-ceramide alone or in combination with gemcitabine against human head and neck squamous cell carcinomas in vitro and in vivo.
Senkal CE, Ponnusamy S, Rossi MJ, Sundararaj K, Szulc Z, Bielawski J, Bielawska A, Meyer M, Cobanoglu B, Koybasi S, Sinha D, Day TA, Obeid LM, Hannun YA, Ogretmen B. Senkal CE, et al. Among authors: bielawski j. J Pharmacol Exp Ther. 2006 Jun;317(3):1188-99. doi: 10.1124/jpet.106.101949. Epub 2006 Mar 1. J Pharmacol Exp Ther. 2006. PMID: 16510697
Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis.
Karahatay S, Thomas K, Koybasi S, Senkal CE, Elojeimy S, Liu X, Bielawski J, Day TA, Gillespie MB, Sinha D, Norris JS, Hannun YA, Ogretmen B. Karahatay S, et al. Among authors: bielawski j. Cancer Lett. 2007 Oct 18;256(1):101-11. doi: 10.1016/j.canlet.2007.06.003. Epub 2007 Jul 9. Cancer Lett. 2007. PMID: 17619081 Free PMC article. Clinical Trial.
A role of sphingosine kinase 1 in head and neck carcinogenesis.
Shirai K, Kaneshiro T, Wada M, Furuya H, Bielawski J, Hannun YA, Obeid LM, Ogretmen B, Kawamori T. Shirai K, et al. Among authors: bielawski j. Cancer Prev Res (Phila). 2011 Mar;4(3):454-62. doi: 10.1158/1940-6207.CAPR-10-0299. Epub 2011 Jan 5. Cancer Prev Res (Phila). 2011. PMID: 21209394 Free PMC article.
Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK.
Kitatani K, Idkowiak-Baldys J, Bielawski J, Taha TA, Jenkins RW, Senkal CE, Ogretmen B, Obeid LM, Hannun YA. Kitatani K, et al. Among authors: bielawski j. J Biol Chem. 2006 Dec 1;281(48):36793-802. doi: 10.1074/jbc.M608137200. Epub 2006 Oct 9. J Biol Chem. 2006. PMID: 17030510 Free article.
Recently we showed that, in human breast cancer cells, activation of protein kinase C by 4beta-phorbol 12-myristate 13-acetate (PMA) produced ceramide formed from the salvage pathway (Becker, K. P., Kitatani, K., Idkowiak-Baldys, J., Bielawski, J., and Hannun …
Recently we showed that, in human breast cancer cells, activation of protein kinase C by 4beta-phorbol 12-myristate 13-acetate (PMA) produce …
Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular Ca2+ and ER/Golgi membrane network.
Senkal CE, Ponnusamy S, Manevich Y, Meyers-Needham M, Saddoughi SA, Mukhopadyay A, Dent P, Bielawski J, Ogretmen B. Senkal CE, et al. Among authors: bielawski j. J Biol Chem. 2011 Dec 9;286(49):42446-42458. doi: 10.1074/jbc.M111.287383. Epub 2011 Oct 19. J Biol Chem. 2011. PMID: 22013072 Free PMC article.
Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy.
Sentelle RD, Senkal CE, Jiang W, Ponnusamy S, Gencer S, Selvam SP, Ramshesh VK, Peterson YK, Lemasters JJ, Szulc ZM, Bielawski J, Ogretmen B. Sentelle RD, et al. Among authors: bielawski j. Nat Chem Biol. 2012 Oct;8(10):831-8. doi: 10.1038/nchembio.1059. Nat Chem Biol. 2012. PMID: 22922758 Free PMC article.
Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis.
Saddoughi SA, Gencer S, Peterson YK, Ward KE, Mukhopadhyay A, Oaks J, Bielawski J, Szulc ZM, Thomas RJ, Selvam SP, Senkal CE, Garrett-Mayer E, De Palma RM, Fedarovich D, Liu A, Habib AA, Stahelin RV, Perrotti D, Ogretmen B. Saddoughi SA, et al. Among authors: bielawski j. EMBO Mol Med. 2013 Jan;5(1):105-21. doi: 10.1002/emmm.201201283. Epub 2012 Nov 25. EMBO Mol Med. 2013. PMID: 23180565 Free PMC article.
327 results