Hannun YA - Search Results

1

Results of a phase II trial of gemcitabine plus doxorubicin in patients with recurrent head and neck cancers: serum C₁₈-ceramide as a novel biomarker for monitoring response.

Saddoughi SA, Garrett-Mayer E, Chaudhary U, O'Brien PE, Afrin LB, Day TA, Gillespie MB, Sharma AK, Wilhoit CS, Bostick R, Senkal CE, Hannun YA, Bielawski J, Simon GR, Shirai K, Ogretmen B. Saddoughi SA, et al. Among authors: hannun ya. Clin Cancer Res. 2011 Sep 15;17(18):6097-105. doi: 10.1158/1078-0432.CCR-11-0930. Epub 2011 Jul 26. Clin Cancer Res. 2011. PMID: 21791630 Free PMC article. Clinical Trial.

2

Role of ceramide in mediating the inhibition of telomerase activity in A549 human lung adenocarcinoma cells.

Ogretmen B, Schady D, Usta J, Wood R, Kraveka JM, Luberto C, Birbes H, Hannun YA, Obeid LM. Ogretmen B, et al. Among authors: hannun ya. J Biol Chem. 2001 Jul 6;276(27):24901-10. doi: 10.1074/jbc.M100314200. Epub 2001 May 2. J Biol Chem. 2001. PMID: 11335714 Free article.

3

Molecular mechanisms of ceramide-mediated telomerase inhibition in the A549 human lung adenocarcinoma cell line.

Ogretmen B, Kraveka JM, Schady D, Usta J, Hannun YA, Obeid LM. Ogretmen B, et al. Among authors: hannun ya. J Biol Chem. 2001 Aug 31;276(35):32506-14. doi: 10.1074/jbc.M101350200. Epub 2001 Jul 5. J Biol Chem. 2001. PMID: 11441001 Free article.

4

Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: modulation of cellular activity of sphingosine 1-phosphate.

Boujaoude LC, Bradshaw-Wilder C, Mao C, Cohn J, Ogretmen B, Hannun YA, Obeid LM. Boujaoude LC, et al. Among authors: hannun ya. J Biol Chem. 2001 Sep 21;276(38):35258-64. doi: 10.1074/jbc.M105442200. Epub 2001 Jul 6. J Biol Chem. 2001. PMID: 11443135 Free article.

5

FAS activation induces dephosphorylation of SR proteins; dependence on the de novo generation of ceramide and activation of protein phosphatase 1.

Chalfant CE, Ogretmen B, Galadari S, Kroesen BJ, Pettus BJ, Hannun YA. Chalfant CE, et al. Among authors: hannun ya. J Biol Chem. 2001 Nov 30;276(48):44848-55. doi: 10.1074/jbc.M106291200. Epub 2001 Aug 13. J Biol Chem. 2001. PMID: 11502750 Free article.

6

De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1.

Chalfant CE, Rathman K, Pinkerman RL, Wood RE, Obeid LM, Ogretmen B, Hannun YA. Chalfant CE, et al. Among authors: hannun ya. J Biol Chem. 2002 Apr 12;277(15):12587-95. doi: 10.1074/jbc.M112010200. Epub 2002 Jan 18. J Biol Chem. 2002. PMID: 11801602 Free article.

7

Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A549 human lung adenocarcinoma cell line. Role for endogenous ceramide in mediating the action of exogenous ceramide.

Ogretmen B, Pettus BJ, Rossi MJ, Wood R, Usta J, Szulc Z, Bielawska A, Obeid LM, Hannun YA. Ogretmen B, et al. Among authors: hannun ya. J Biol Chem. 2002 Apr 12;277(15):12960-9. doi: 10.1074/jbc.M110699200. Epub 2002 Jan 28. J Biol Chem. 2002. PMID: 11815611 Free article.

8

Updates on functions of ceramide in chemotherapy-induced cell death and in multidrug resistance.

Ogretmen B, Hannun YA. Ogretmen B, et al. Among authors: hannun ya. Drug Resist Updat. 2001 Dec;4(6):368-77. doi: 10.1054/drup.2001.0225. Drug Resist Updat. 2001. PMID: 12030784 Review.

9

The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha.

Pettus BJ, Bielawski J, Porcelli AM, Reames DL, Johnson KR, Morrow J, Chalfant CE, Obeid LM, Hannun YA. Pettus BJ, et al. Among authors: hannun ya. FASEB J. 2003 Aug;17(11):1411-21. doi: 10.1096/fj.02-1038com. FASEB J. 2003. PMID: 12890694

10

Rapid shortening of telomere length in response to ceramide involves the inhibition of telomere binding activity of nuclear glyceraldehyde-3-phosphate dehydrogenase.

Sundararaj KP, Wood RE, Ponnusamy S, Salas AM, Szulc Z, Bielawska A, Obeid LM, Hannun YA, Ogretmen B. Sundararaj KP, et al. Among authors: hannun ya. J Biol Chem. 2004 Feb 13;279(7):6152-62. doi: 10.1074/jbc.M310549200. Epub 2003 Nov 20. J Biol Chem. 2004. PMID: 14630908 Free article.

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