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Pathogenic LRRK2 mutations do not alter gene expression in cell model systems or human brain tissue.
Devine MJ, Kaganovich A, Ryten M, Mamais A, Trabzuni D, Manzoni C, McGoldrick P, Chan D, Dillman A, Zerle J, Horan S, Taanman JW, Hardy J, Marti-Masso JF, Healy D, Schapira AH, Wolozin B, Bandopadhyay R, Cookson MR, van der Brug MP, Lewis PA. Devine MJ, et al. Among authors: wolozin b. PLoS One. 2011;6(7):e22489. doi: 10.1371/journal.pone.0022489. Epub 2011 Jul 22. PLoS One. 2011. PMID: 21799870 Free PMC article.
LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans.
Saha S, Guillily MD, Ferree A, Lanceta J, Chan D, Ghosh J, Hsu CH, Segal L, Raghavan K, Matsumoto K, Hisamoto N, Kuwahara T, Iwatsubo T, Moore L, Goldstein L, Cookson M, Wolozin B. Saha S, et al. Among authors: wolozin b. J Neurosci. 2009 Jul 22;29(29):9210-8. doi: 10.1523/JNEUROSCI.2281-09.2009. J Neurosci. 2009. PMID: 19625511 Free PMC article.
MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2.
Hsu CH, Chan D, Greggio E, Saha S, Guillily MD, Ferree A, Raghavan K, Shen GC, Segal L, Ryu H, Cookson MR, Wolozin B. Hsu CH, et al. Among authors: wolozin b. J Neurochem. 2010 Mar;112(6):1593-604. doi: 10.1111/j.1471-4159.2010.06568.x. Epub 2010 Jan 7. J Neurochem. 2010. PMID: 20067578 Free PMC article.
A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity.
Dusonchet J, Li H, Guillily M, Liu M, Stafa K, Derada Troletti C, Boon JY, Saha S, Glauser L, Mamais A, Citro A, Youmans KL, Liu L, Schneider BL, Aebischer P, Yue Z, Bandopadhyay R, Glicksman MA, Moore DJ, Collins JJ, Wolozin B. Dusonchet J, et al. Among authors: wolozin b. Hum Mol Genet. 2014 Sep 15;23(18):4887-905. doi: 10.1093/hmg/ddu202. Epub 2014 May 2. Hum Mol Genet. 2014. PMID: 24794857 Free PMC article.
186 results