Gray NS - Search Results

1

High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors.

Miduturu CV, Deng X, Kwiatkowski N, Yang W, Brault L, Filippakopoulos P, Chung E, Yang Q, Schwaller J, Knapp S, King RW, Lee JD, Herrgard S, Zarrinkar P, Gray NS. Miduturu CV, et al. Among authors: gray ns. Chem Biol. 2011 Jul 29;18(7):868-79. doi: 10.1016/j.chembiol.2011.05.010. Chem Biol. 2011. PMID: 21802008 Free PMC article.

2

Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors.

Chang YT, Gray NS, Rosania GR, Sutherlin DP, Kwon S, Norman TC, Sarohia R, Leost M, Meijer L, Schultz PG. Chang YT, et al. Among authors: gray ns. Chem Biol. 1999 Jun;6(6):361-75. doi: 10.1016/S1074-5521(99)80048-9. Chem Biol. 1999. PMID: 10375538

3

A genome-wide overexpression screen in yeast for small-molecule target identification.

Luesch H, Wu TY, Ren P, Gray NS, Schultz PG, Supek F. Luesch H, et al. Among authors: gray ns. Chem Biol. 2005 Jan;12(1):55-63. doi: 10.1016/j.chembiol.2004.10.015. Chem Biol. 2005. PMID: 15664515

4

Rational design of inhibitors that bind to inactive kinase conformations.

Liu Y, Gray NS. Liu Y, et al. Among authors: gray ns. Nat Chem Biol. 2006 Jul;2(7):358-64. doi: 10.1038/nchembio799. Nat Chem Biol. 2006. PMID: 16783341

5

A general strategy for creating "inactive-conformation" abl inhibitors.

Okram B, Nagle A, Adrián FJ, Lee C, Ren P, Wang X, Sim T, Xie Y, Wang X, Xia G, Spraggon G, Warmuth M, Liu Y, Gray NS. Okram B, et al. Among authors: gray ns. Chem Biol. 2006 Jul;13(7):779-86. doi: 10.1016/j.chembiol.2006.05.015. Chem Biol. 2006. PMID: 16873026

6

Identification of human kinases involved in hepatitis C virus replication by small interference RNA library screening.

Supekova L, Supek F, Lee J, Chen S, Gray N, Pezacki JP, Schlapbach A, Schultz PG. Supekova L, et al. J Biol Chem. 2008 Jan 4;283(1):29-36. doi: 10.1074/jbc.M703988200. Epub 2007 Oct 19. J Biol Chem. 2008. PMID: 17951261 Free article.

7

Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling.

McDermott U, Sharma SV, Dowell L, Greninger P, Montagut C, Lamb J, Archibald H, Raudales R, Tam A, Lee D, Rothenberg SM, Supko JG, Sordella R, Ulkus LE, Iafrate AJ, Maheswaran S, Njauw CN, Tsao H, Drew L, Hanke JH, Ma XJ, Erlander MG, Gray NS, Haber DA, Settleman J. McDermott U, et al. Among authors: gray ns. Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19936-41. doi: 10.1073/pnas.0707498104. Epub 2007 Dec 6. Proc Natl Acad Sci U S A. 2007. PMID: 18077425 Free PMC article.

8

Discovery of selective aminothiazole aurora kinase inhibitors.

Andersen CB, Wan Y, Chang JW, Riggs B, Lee C, Liu Y, Sessa F, Villa F, Kwiatkowski N, Suzuki M, Nallan L, Heald R, Musacchio A, Gray NS. Andersen CB, et al. Among authors: gray ns. ACS Chem Biol. 2008 Mar 20;3(3):180-92. doi: 10.1021/cb700200w. Epub 2008 Feb 29. ACS Chem Biol. 2008. PMID: 18307303

9

High-throughput kinase profiling as a platform for drug discovery.

Goldstein DM, Gray NS, Zarrinkar PP. Goldstein DM, et al. Among authors: gray ns. Nat Rev Drug Discov. 2008 May;7(5):391-7. doi: 10.1038/nrd2541. Nat Rev Drug Discov. 2008. PMID: 18404149 Review.

10

Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors.

McDermott U, Iafrate AJ, Gray NS, Shioda T, Classon M, Maheswaran S, Zhou W, Choi HG, Smith SL, Dowell L, Ulkus LE, Kuhlmann G, Greninger P, Christensen JG, Haber DA, Settleman J. McDermott U, et al. Among authors: gray ns. Cancer Res. 2008 May 1;68(9):3389-95. doi: 10.1158/0008-5472.CAN-07-6186. Cancer Res. 2008. PMID: 18451166

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