Lee JD - Search Results

1

High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors.

Miduturu CV, Deng X, Kwiatkowski N, Yang W, Brault L, Filippakopoulos P, Chung E, Yang Q, Schwaller J, Knapp S, King RW, Lee JD, Herrgard S, Zarrinkar P, Gray NS. Miduturu CV, et al. Among authors: lee jd. Chem Biol. 2011 Jul 29;18(7):868-79. doi: 10.1016/j.chembiol.2011.05.010. Chem Biol. 2011. PMID: 21802008 Free PMC article.

2

Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2.

Deng X, Dzamko N, Prescott A, Davies P, Liu Q, Yang Q, Lee JD, Patricelli MP, Nomanbhoy TK, Alessi DR, Gray NS. Deng X, et al. Among authors: lee jd. Nat Chem Biol. 2011 Apr;7(4):203-5. doi: 10.1038/nchembio.538. Epub 2011 Mar 6. Nat Chem Biol. 2011. PMID: 21378983 Free PMC article.

3

Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones.

Deng X, Elkins JM, Zhang J, Yang Q, Erazo T, Gomez N, Choi HG, Wang J, Dzamko N, Lee JD, Sim T, Kim N, Alessi DR, Lizcano JM, Knapp S, Gray NS. Deng X, et al. Among authors: lee jd. Eur J Med Chem. 2013;70:758-67. doi: 10.1016/j.ejmech.2013.10.052. Epub 2013 Oct 29. Eur J Med Chem. 2013. PMID: 24239623 Free PMC article.

4

In situ kinase profiling reveals functionally relevant properties of native kinases.

Patricelli MP, Nomanbhoy TK, Wu J, Brown H, Zhou D, Zhang J, Jagannathan S, Aban A, Okerberg E, Herring C, Nordin B, Weissig H, Yang Q, Lee JD, Gray NS, Kozarich JW. Patricelli MP, et al. Among authors: lee jd. Chem Biol. 2011 Jun 24;18(6):699-710. doi: 10.1016/j.chembiol.2011.04.011. Chem Biol. 2011. PMID: 21700206 Free PMC article.

5

Discovery of a benzo[e]pyrimido-[5,4-b][1,4]diazepin-6(11H)-one as a Potent and Selective Inhibitor of Big MAP Kinase 1.

Deng X, Yang Q, Kwiatkowski N, Sim T, McDermott U, Settleman JE, Lee JD, Gray NS. Deng X, et al. Among authors: lee jd. ACS Med Chem Lett. 2011 Mar 10;2(3):195-200. doi: 10.1021/ml100304b. Epub 2011 Jan 12. ACS Med Chem Lett. 2011. PMID: 21412406 Free PMC article.

6

Targeting the BMK1 MAP kinase pathway in cancer therapy.

Yang Q, Lee JD. Yang Q, et al. Among authors: lee jd. Clin Cancer Res. 2011 Jun 1;17(11):3527-32. doi: 10.1158/1078-0432.CCR-10-2504. Epub 2011 Mar 8. Clin Cancer Res. 2011. PMID: 21385929 Free PMC article.

7

Kinome siRNA screen identifies SMG-1 as a negative regulator of hypoxia-inducible factor-1alpha in hypoxia.

Chen RQ, Yang QK, Chen YL, Oliveira VA, Dalton WS, Fearns C, Lee JD. Chen RQ, et al. Among authors: lee jd. J Biol Chem. 2009 Jun 19;284(25):16752-16758. doi: 10.1074/jbc.M109.014316. Epub 2009 Apr 30. J Biol Chem. 2009. PMID: 19406746 Free PMC article.

8

BMK1 kinase suppresses epithelial-mesenchymal transition through the Akt/GSK3β signaling pathway.

Chen R, Yang Q, Lee JD. Chen R, et al. Among authors: lee jd. Cancer Res. 2012 Mar 15;72(6):1579-87. doi: 10.1158/0008-5472.CAN-11-2055. Epub 2012 Jan 26. Cancer Res. 2012. PMID: 22282661 Free PMC article.

9

Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein.

Yang Q, Deng X, Lu B, Cameron M, Fearns C, Patricelli MP, Yates JR 3rd, Gray NS, Lee JD. Yang Q, et al. Among authors: lee jd. Cancer Cell. 2010 Sep 14;18(3):258-67. doi: 10.1016/j.ccr.2010.08.008. Cancer Cell. 2010. PMID: 20832753 Free PMC article.

10

Targeting BMK1 Impairs the Drug Resistance to Combined Inhibition of BRAF and MEK1/2 in Melanoma.

Song C, Wang L, Xu Q, Wang K, Xie D, Yu Z, Jiang K, Liao L, Yates JR, Lee JD, Yang Q. Song C, et al. Among authors: lee jd. Sci Rep. 2017 Apr 7;7:46244. doi: 10.1038/srep46244. Sci Rep. 2017. PMID: 28387310 Free PMC article.

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