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AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics.
Kuai L, Ong SE, Madison JM, Wang X, Duvall JR, Lewis TA, Luce CJ, Conner SD, Pearlman DA, Wood JL, Schreiber SL, Carr SA, Scolnick EM, Haggarty SJ. Kuai L, et al. Among authors: lewis ta. Chem Biol. 2011 Jul 29;18(7):891-906. doi: 10.1016/j.chembiol.2011.03.017. Chem Biol. 2011. PMID: 21802010 Free PMC article.
A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint.
van Vugt MA, Gardino AK, Linding R, Ostheimer GJ, Reinhardt HC, Ong SE, Tan CS, Miao H, Keezer SM, Li J, Pawson T, Lewis TA, Carr SA, Smerdon SJ, Brummelkamp TR, Yaffe MB. van Vugt MA, et al. Among authors: lewis ta. PLoS Biol. 2010 Jan 26;8(1):e1000287. doi: 10.1371/journal.pbio.1000287. PLoS Biol. 2010. PMID: 20126263 Free PMC article.
Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics.
de Waal L, Lewis TA, Rees MG, Tsherniak A, Wu X, Choi PS, Gechijian L, Hartigan C, Faloon PW, Hickey MJ, Tolliday N, Carr SA, Clemons PA, Munoz B, Wagner BK, Shamji AF, Koehler AN, Schenone M, Burgin AB, Schreiber SL, Greulich H, Meyerson M. de Waal L, et al. Among authors: lewis ta. Nat Chem Biol. 2016 Feb;12(2):102-8. doi: 10.1038/nchembio.1984. Epub 2015 Dec 14. Nat Chem Biol. 2016. PMID: 26656089 Free PMC article.
Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.
Sarkar S, Perlstein EO, Imarisio S, Pineau S, Cordenier A, Maglathlin RL, Webster JA, Lewis TA, O'Kane CJ, Schreiber SL, Rubinsztein DC. Sarkar S, et al. Among authors: lewis ta. Nat Chem Biol. 2007 Jun;3(6):331-8. doi: 10.1038/nchembio883. Epub 2007 May 7. Nat Chem Biol. 2007. PMID: 17486044 Free PMC article.
Identification of a selective small molecule inhibitor of breast cancer stem cells.
Germain AR, Carmody LC, Morgan B, Fernandez C, Forbeck E, Lewis TA, Nag PP, Ting A, VerPlank L, Feng Y, Perez JR, Dandapani S, Palmer M, Lander ES, Gupta PB, Schreiber SL, Munoz B. Germain AR, et al. Among authors: lewis ta. Bioorg Med Chem Lett. 2012 May 15;22(10):3571-4. doi: 10.1016/j.bmcl.2012.01.035. Epub 2012 Jan 25. Bioorg Med Chem Lett. 2012. PMID: 22503247
107 results