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AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics.
Kuai L, Ong SE, Madison JM, Wang X, Duvall JR, Lewis TA, Luce CJ, Conner SD, Pearlman DA, Wood JL, Schreiber SL, Carr SA, Scolnick EM, Haggarty SJ. Kuai L, et al. Among authors: scolnick em. Chem Biol. 2011 Jul 29;18(7):891-906. doi: 10.1016/j.chembiol.2011.03.017. Chem Biol. 2011. PMID: 21802010 Free PMC article.
AKT kinase activity is required for lithium to modulate mood-related behaviors in mice.
Pan JQ, Lewis MC, Ketterman JK, Clore EL, Riley M, Richards KR, Berry-Scott E, Liu X, Wagner FF, Holson EB, Neve RL, Biechele TL, Moon RT, Scolnick EM, Petryshen TL, Haggarty SJ. Pan JQ, et al. Among authors: scolnick em. Neuropsychopharmacology. 2011 Jun;36(7):1397-411. doi: 10.1038/npp.2011.24. Epub 2011 Mar 9. Neuropsychopharmacology. 2011. PMID: 21389981 Free PMC article.
A polygenic burden of rare disruptive mutations in schizophrenia.
Purcell SM, Moran JL, Fromer M, Ruderfer D, Solovieff N, Roussos P, O'Dushlaine C, Chambert K, Bergen SE, Kähler A, Duncan L, Stahl E, Genovese G, Fernández E, Collins MO, Komiyama NH, Choudhary JS, Magnusson PK, Banks E, Shakir K, Garimella K, Fennell T, DePristo M, Grant SG, Haggarty SJ, Gabriel S, Scolnick EM, Lander ES, Hultman CM, Sullivan PF, McCarroll SA, Sklar P. Purcell SM, et al. Among authors: scolnick em. Nature. 2014 Feb 13;506(7487):185-90. doi: 10.1038/nature12975. Epub 2014 Jan 22. Nature. 2014. PMID: 24463508 Free PMC article.
Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers.
Wagner FF, Zhang YL, Fass DM, Joseph N, Gale JP, Weïwer M, McCarren P, Fisher SL, Kaya T, Zhao WN, Reis SA, Hennig KM, Thomas M, Lemercier BC, Lewis MC, Guan JS, Moyer MP, Scolnick E, Haggarty SJ, Tsai LH, Holson EB. Wagner FF, et al. Chem Sci. 2015 Jan 1;6(1):804-815. doi: 10.1039/C4SC02130D. Chem Sci. 2015. PMID: 25642316 Free PMC article.
Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects.
Wagner FF, Bishop JA, Gale JP, Shi X, Walk M, Ketterman J, Patnaik D, Barker D, Walpita D, Campbell AJ, Nguyen S, Lewis M, Ross L, Weïwer M, An WF, Germain AR, Nag PP, Metkar S, Kaya T, Dandapani S, Olson DE, Barbe AL, Lazzaro F, Sacher JR, Cheah JH, Fei D, Perez J, Munoz B, Palmer M, Stegmaier K, Schreiber SL, Scolnick E, Zhang YL, Haggarty SJ, Holson EB, Pan JQ. Wagner FF, et al. ACS Chem Biol. 2016 Jul 15;11(7):1952-63. doi: 10.1021/acschembio.6b00306. Epub 2016 May 13. ACS Chem Biol. 2016. PMID: 27128528
Functional analysis of rare variants found in schizophrenia implicates a critical role for GIT1-PAK3 signaling in neuroplasticity.
Kim MJ, Biag J, Fass DM, Lewis MC, Zhang Q, Fleishman M, Gangwar SP, Machius M, Fromer M, Purcell SM, McCarroll SA, Rudenko G, Premont RT, Scolnick EM, Haggarty SJ. Kim MJ, et al. Among authors: scolnick em. Mol Psychiatry. 2017 Mar;22(3):417-429. doi: 10.1038/mp.2016.98. Epub 2016 Jul 26. Mol Psychiatry. 2017. PMID: 27457813 Free PMC article.
Selective inhibition of glycogen synthase kinase 3α corrects pathophysiology in a mouse model of fragile X syndrome.
McCamphill PK, Stoppel LJ, Senter RK, Lewis MC, Heynen AJ, Stoppel DC, Sridhar V, Collins KA, Shi X, Pan JQ, Madison J, Cottrell JR, Huber KM, Scolnick EM, Holson EB, Wagner FF, Bear MF. McCamphill PK, et al. Among authors: scolnick em. Sci Transl Med. 2020 May 20;12(544):eaam8572. doi: 10.1126/scitranslmed.aam8572. Sci Transl Med. 2020. PMID: 32434848 Free PMC article.
Regulation of purine metabolism connects KCTD13 to a metabolic disorder with autistic features.
Madison JM, Duong K, Vieux EF, Udeshi ND, Iqbal S, Requadt E, Fereshetian S, Lewis MC, Gomes AS, Pierce KA, Platt RJ, Zhang F, Campbell AJ, Lal D, Wagner FF, Clish CB, Carr SA, Sheng M, Scolnick EM, Cottrell JR. Madison JM, et al. Among authors: scolnick em. iScience. 2020 Dec 11;24(1):101935. doi: 10.1016/j.isci.2020.101935. eCollection 2021 Jan 22. iScience. 2020. PMID: 33409479 Free PMC article.
Brain-specific deletion of GIT1 impairs cognition and alters phosphorylation of synaptic protein networks implicated in schizophrenia susceptibility.
Fass DM, Lewis MC, Ahmad R, Szucs MJ, Zhang Q, Fleishman M, Wang D, Kim MJ, Biag J, Carr SA, Scolnick EM, Premont RT, Haggarty SJ. Fass DM, et al. Among authors: scolnick em. Mol Psychiatry. 2022 Aug;27(8):3272-3285. doi: 10.1038/s41380-022-01557-z. Epub 2022 May 3. Mol Psychiatry. 2022. PMID: 35505090 Free PMC article.
273 results