Hay MP - Search Results

1

Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality.

Chan DA, Sutphin PD, Nguyen P, Turcotte S, Lai EW, Banh A, Reynolds GE, Chi JT, Wu J, Solow-Cordero DE, Bonnet M, Flanagan JU, Bouley DM, Graves EE, Denny WA, Hay MP, Giaccia AJ. Chan DA, et al. Among authors: hay mp. Sci Transl Med. 2011 Aug 3;3(94):94ra70. doi: 10.1126/scitranslmed.3002394. Sci Transl Med. 2011. PMID: 21813754 Free PMC article.

2

A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy.

Turcotte S, Chan DA, Sutphin PD, Hay MP, Denny WA, Giaccia AJ. Turcotte S, et al. Among authors: hay mp. Cancer Cell. 2008 Jul 8;14(1):90-102. doi: 10.1016/j.ccr.2008.06.004. Cancer Cell. 2008. PMID: 18598947 Free PMC article.

3

Identifying novel targets in renal cell carcinoma: design and synthesis of affinity chromatography reagents.

Bonnet M, Flanagan JU, Chan DA, Giaccia AJ, Hay MP. Bonnet M, et al. Among authors: hay mp. Bioorg Med Chem. 2014 Jan 15;22(2):711-20. doi: 10.1016/j.bmc.2013.12.028. Epub 2013 Dec 20. Bioorg Med Chem. 2014. PMID: 24387866 Free PMC article.

4

4-Pyridylanilinothiazoles that selectively target von Hippel-Lindau deficient renal cell carcinoma cells by inducing autophagic cell death.

Hay MP, Turcotte S, Flanagan JU, Bonnet M, Chan DA, Sutphin PD, Nguyen P, Giaccia AJ, Denny WA. Hay MP, et al. J Med Chem. 2010 Jan 28;53(2):787-97. doi: 10.1021/jm901457w. J Med Chem. 2010. PMID: 19994864 Free PMC article.

5

SAR studies of 4-pyridyl heterocyclic anilines that selectively induce autophagic cell death in von Hippel-Lindau-deficient renal cell carcinoma cells.

Bonnet M, Flanagan JU, Chan DA, Lai EW, Nguyen P, Giaccia AJ, Hay MP. Bonnet M, et al. Among authors: hay mp. Bioorg Med Chem. 2011 Jun 1;19(11):3347-56. doi: 10.1016/j.bmc.2011.04.042. Epub 2011 Apr 24. Bioorg Med Chem. 2011. PMID: 21561782 Free PMC article.

6

Improved potency of the hypoxic cytotoxin tirapazamine by DNA-targeting.

Delahoussaye YM, Hay MP, Pruijn FB, Denny WA, Brown JM. Delahoussaye YM, et al. Among authors: hay mp. Biochem Pharmacol. 2003 Jun 1;65(11):1807-15. doi: 10.1016/s0006-2952(03)00199-0. Biochem Pharmacol. 2003. PMID: 12781332 Free PMC article.

7

Acridine Derivatives as Inhibitors of the IRE1α-XBP1 Pathway Are Cytotoxic to Human Multiple Myeloma.

Jiang D, Tam AB, Alagappan M, Hay MP, Gupta A, Kozak MM, Solow-Cordero DE, Lum PY, Denko NC, Giaccia AJ, Le QT, Niwa M, Koong AC. Jiang D, et al. Among authors: hay mp. Mol Cancer Ther. 2016 Sep;15(9):2055-65. doi: 10.1158/1535-7163.MCT-15-1023. Epub 2016 Jun 15. Mol Cancer Ther. 2016. PMID: 27307600 Free PMC article.

8

Dynamin impacts homology-directed repair and breast cancer response to chemotherapy.

Chernikova SB, Nguyen RB, Truong JT, Mello SS, Stafford JH, Hay MP, Olson A, Solow-Cordero DE, Wood DJ, Henry S, von Eyben R, Deng L, Gephart MH, Aroumougame A, Wiese C, Game JC, Győrffy B, Brown JM. Chernikova SB, et al. Among authors: hay mp. J Clin Invest. 2018 Dec 3;128(12):5307-5321. doi: 10.1172/JCI87191. Epub 2018 Oct 29. J Clin Invest. 2018. PMID: 30371505 Free PMC article.

9

Nitroarylmethylcarbamate prodrugs of doxorubicin for use with nitroreductase gene-directed enzyme prodrug therapy.

Hay MP, Wilson WR, Denny WA. Hay MP, et al. Bioorg Med Chem. 2005 Jun 2;13(12):4043-55. doi: 10.1016/j.bmc.2005.03.055. Epub 2005 Apr 25. Bioorg Med Chem. 2005. PMID: 15911317

10

Nitrobenzyl carbamate prodrugs of enediynes for nitroreductase gene-directed enzyme prodrug therapy (GDEPT).

Hay MP, Wilson WR, Denny WA. Hay MP, et al. Bioorg Med Chem Lett. 1999 Dec 20;9(24):3417-22. doi: 10.1016/s0960-894x(99)00627-7. Bioorg Med Chem Lett. 1999. PMID: 10617083

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