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Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA.
Fehrmann RS, Jansen RC, Veldink JH, Westra HJ, Arends D, Bonder MJ, Fu J, Deelen P, Groen HJ, Smolonska A, Weersma RK, Hofstra RM, Buurman WA, Rensen S, Wolfs MG, Platteel M, Zhernakova A, Elbers CC, Festen EM, Trynka G, Hofker MH, Saris CG, Ophoff RA, van den Berg LH, van Heel DA, Wijmenga C, Te Meerman GJ, Franke L. Fehrmann RS, et al. Among authors: buurman wa. PLoS Genet. 2011 Aug;7(8):e1002197. doi: 10.1371/journal.pgen.1002197. Epub 2011 Aug 4. PLoS Genet. 2011. PMID: 21829388 Free PMC article.
Unraveling the regulatory mechanisms underlying tissue-dependent genetic variation of gene expression.
Fu J, Wolfs MG, Deelen P, Westra HJ, Fehrmann RS, Te Meerman GJ, Buurman WA, Rensen SS, Groen HJ, Weersma RK, van den Berg LH, Veldink J, Ophoff RA, Snieder H, van Heel D, Jansen RC, Hofker MH, Wijmenga C, Franke L. Fu J, et al. Among authors: buurman wa. PLoS Genet. 2012 Jan;8(1):e1002431. doi: 10.1371/journal.pgen.1002431. Epub 2012 Jan 19. PLoS Genet. 2012. PMID: 22275870 Free PMC article.
Genetic and epigenetic regulation of gene expression in fetal and adult human livers.
Bonder MJ, Kasela S, Kals M, Tamm R, Lokk K, Barragan I, Buurman WA, Deelen P, Greve JW, Ivanov M, Rensen SS, van Vliet-Ostaptchouk JV, Wolfs MG, Fu J, Hofker MH, Wijmenga C, Zhernakova A, Ingelman-Sundberg M, Franke L, Milani L. Bonder MJ, et al. Among authors: buurman wa. BMC Genomics. 2014 Oct 4;15(1):860. doi: 10.1186/1471-2164-15-860. BMC Genomics. 2014. PMID: 25282492 Free PMC article.
Co-expressed immune and metabolic genes in visceral and subcutaneous adipose tissue from severely obese individuals are associated with plasma HDL and glucose levels: a microarray study.
Wolfs MG, Rensen SS, Bruin-Van Dijk EJ, Verdam FJ, Greve JW, Sanjabi B, Bruinenberg M, Wijmenga C, van Haeften TW, Buurman WA, Franke L, Hofker MH. Wolfs MG, et al. Among authors: buurman wa. BMC Med Genomics. 2010 Aug 5;3:34. doi: 10.1186/1755-8794-3-34. BMC Med Genomics. 2010. PMID: 20687939 Free PMC article.
Plasma cholesteryl ester transfer protein is predominantly derived from Kupffer cells.
Wang Y, van der Tuin S, Tjeerdema N, van Dam AD, Rensen SS, Hendrikx T, Berbée JF, Atanasovska B, Fu J, Hoekstra M, Bekkering S, Riksen NP, Buurman WA, Greve JW, Hofker MH, Shiri-Sverdlov R, Meijer OC, Smit JW, Havekes LM, van Dijk KW, Rensen PC. Wang Y, et al. Among authors: buurman wa. Hepatology. 2015 Dec;62(6):1710-22. doi: 10.1002/hep.27985. Epub 2015 Aug 28. Hepatology. 2015. PMID: 26174697
Complement alternative pathway activation in human nonalcoholic steatohepatitis.
Segers FM, Verdam FJ, de Jonge C, Boonen B, Driessen A, Shiri-Sverdlov R, Bouvy ND, Greve JW, Buurman WA, Rensen SS. Segers FM, et al. Among authors: buurman wa. PLoS One. 2014 Oct 9;9(10):e110053. doi: 10.1371/journal.pone.0110053. eCollection 2014. PLoS One. 2014. PMID: 25299043 Free PMC article.
Plasma cathepsin D correlates with histological classifications of fatty liver disease in adults and responds to intervention.
Walenbergh SM, Houben T, Rensen SS, Bieghs V, Hendrikx T, van Gorp PJ, Oligschlaeger Y, Jeurissen ML, Gijbels MJ, Buurman WA, Vreugdenhil AC, Greve JW, Plat J, Hofker MH, Kalhan S, Pihlajamäki J, Lindsey P, Koek GH, Shiri-Sverdlov R. Walenbergh SM, et al. Among authors: buurman wa. Sci Rep. 2016 Dec 6;6:38278. doi: 10.1038/srep38278. Sci Rep. 2016. PMID: 27922112 Free PMC article.
511 results