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Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA.
Fehrmann RS, Jansen RC, Veldink JH, Westra HJ, Arends D, Bonder MJ, Fu J, Deelen P, Groen HJ, Smolonska A, Weersma RK, Hofstra RM, Buurman WA, Rensen S, Wolfs MG, Platteel M, Zhernakova A, Elbers CC, Festen EM, Trynka G, Hofker MH, Saris CG, Ophoff RA, van den Berg LH, van Heel DA, Wijmenga C, Te Meerman GJ, Franke L. Fehrmann RS, et al. Among authors: hofker mh. PLoS Genet. 2011 Aug;7(8):e1002197. doi: 10.1371/journal.pgen.1002197. Epub 2011 Aug 4. PLoS Genet. 2011. PMID: 21829388 Free PMC article.
Unraveling the regulatory mechanisms underlying tissue-dependent genetic variation of gene expression.
Fu J, Wolfs MG, Deelen P, Westra HJ, Fehrmann RS, Te Meerman GJ, Buurman WA, Rensen SS, Groen HJ, Weersma RK, van den Berg LH, Veldink J, Ophoff RA, Snieder H, van Heel D, Jansen RC, Hofker MH, Wijmenga C, Franke L. Fu J, et al. Among authors: hofker mh. PLoS Genet. 2012 Jan;8(1):e1002431. doi: 10.1371/journal.pgen.1002431. Epub 2012 Jan 19. PLoS Genet. 2012. PMID: 22275870 Free PMC article.
Human disease-associated genetic variation impacts large intergenic non-coding RNA expression.
Kumar V, Westra HJ, Karjalainen J, Zhernakova DV, Esko T, Hrdlickova B, Almeida R, Zhernakova A, Reinmaa E, Võsa U, Hofker MH, Fehrmann RS, Fu J, Withoff S, Metspalu A, Franke L, Wijmenga C. Kumar V, et al. Among authors: hofker mh. PLoS Genet. 2013;9(1):e1003201. doi: 10.1371/journal.pgen.1003201. Epub 2013 Jan 17. PLoS Genet. 2013. PMID: 23341781 Free PMC article.
Genetic and epigenetic regulation of gene expression in fetal and adult human livers.
Bonder MJ, Kasela S, Kals M, Tamm R, Lokk K, Barragan I, Buurman WA, Deelen P, Greve JW, Ivanov M, Rensen SS, van Vliet-Ostaptchouk JV, Wolfs MG, Fu J, Hofker MH, Wijmenga C, Zhernakova A, Ingelman-Sundberg M, Franke L, Milani L. Bonder MJ, et al. Among authors: hofker mh. BMC Genomics. 2014 Oct 4;15(1):860. doi: 10.1186/1471-2164-15-860. BMC Genomics. 2014. PMID: 25282492 Free PMC article.
A supersized list of obesity genes.
Hofker M, Wijmenga C. Hofker M, et al. Nat Genet. 2009 Feb;41(2):139-40. doi: 10.1038/ng0209-139. Nat Genet. 2009. PMID: 19174833 No abstract available.
Apple or pear: size and shape matter.
Fu J, Hofker M, Wijmenga C. Fu J, et al. Cell Metab. 2015 Apr 7;21(4):507-8. doi: 10.1016/j.cmet.2015.03.016. Cell Metab. 2015. PMID: 25863240 Free article.
HHEX gene polymorphisms are associated with type 2 diabetes in the Dutch Breda cohort.
van Vliet-Ostaptchouk JV, Onland-Moret NC, van Haeften TW, Franke L, Elbers CC, Shiri-Sverdlov R, van der Schouw YT, Hofker MH, Wijmenga C. van Vliet-Ostaptchouk JV, et al. Among authors: hofker mh. Eur J Hum Genet. 2008 May;16(5):652-6. doi: 10.1038/sj.ejhg.5202008. Epub 2008 Jan 30. Eur J Hum Genet. 2008. PMID: 18231124
Co-expressed immune and metabolic genes in visceral and subcutaneous adipose tissue from severely obese individuals are associated with plasma HDL and glucose levels: a microarray study.
Wolfs MG, Rensen SS, Bruin-Van Dijk EJ, Verdam FJ, Greve JW, Sanjabi B, Bruinenberg M, Wijmenga C, van Haeften TW, Buurman WA, Franke L, Hofker MH. Wolfs MG, et al. Among authors: hofker mh. BMC Med Genomics. 2010 Aug 5;3:34. doi: 10.1186/1755-8794-3-34. BMC Med Genomics. 2010. PMID: 20687939 Free PMC article.
265 results